Gene interactions and pathways from curated databases and text-mining

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MIF — SOCS1

Text-mined interactions from Literome

Kleemann et al., Nature 2000 : MIF inhibits Jab1- and stimulus enhanced AP-1 activity, but does not interfere with the induction of the transcription factor NFkappaB
Burger-Kentischer et al., FEBS Lett 2005 : YTH and pull-down analysis in conjunction with nanobead affinity matrix assisted laser desorption ionization-time of flight ( MALDI-TOF ) mass spectrometry demonstrated that MIF ( 50-65 ) and MPN are sufficient to mediate MIF-JAB1 interaction, respectively
Lue et al., Cell Signal 2006 (MAP Kinase Signaling System) : By contrast, JAB1-knock-down by siRNA revealed that minimum JAB1 levels were necessary for transient activation of ERK by MIF
Nemajerova et al., EMBO J 2007 (Genomic Instability...) : Given that CSN plays a central role in the assembly of SCF complexes in vivo, regulation of Jab1/CSN5 by MIF is required to sustain optimal composition and function of the SCF complex