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MIF — SOCS1
Text-mined interactions from Literome
Kleemann et al., Nature 2000
:
MIF inhibits
Jab1- and stimulus enhanced AP-1 activity, but does not interfere with the induction of the transcription factor NFkappaB
Burger-Kentischer et al., FEBS Lett 2005
:
YTH and pull-down analysis in conjunction with nanobead affinity matrix assisted laser desorption ionization-time of flight ( MALDI-TOF ) mass spectrometry demonstrated that
MIF ( 50-65 ) and MPN are
sufficient to mediate
MIF-JAB1 interaction, respectively
Lue et al., Cell Signal 2006
(MAP Kinase Signaling System) :
By contrast, JAB1-knock-down by siRNA revealed that minimum
JAB1 levels were
necessary for transient activation of ERK by
MIF
Nemajerova et al., EMBO J 2007
(Genomic Instability...) :
Given that CSN plays a central role in the assembly of SCF complexes in vivo,
regulation of
Jab1/CSN5 by
MIF is required to sustain optimal composition and function of the SCF complex