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LIPE — PRKAG1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Watt et al., FASEB J 2004
:
The exercise induced increase in
HSL activity was
attenuated by
AMPK alpha-2 activation in LG ... To confirm the apparent
effect of
AMPK on
HSL activity, we performed experiments in muscle cell culture
Roepstorff et al., J Physiol 2004
:
The main purpose of the present study was to investigate the
role of
5'AMP activated protein kinase (AMPK) in the regulation of muscle
HSL activity and Ser565 phosphorylation ( the presumed AMPK target site ) in healthy, moderately trained men during 60 min bicycling ( 65 % ) ... Alternatively, other factors including ERK may have counterbalanced any
effect of
AMPK on
HSL activity
Watt et al., Am J Physiol Endocrinol Metab 2006
:
We investigated the
effects of adrenergic stimulation and
AMPK activation in vitro and in circumstances where AMPK activity and catecholamines are physiologically elevated in humans in vivo ( during physical exercise ) on
HSL activity and phosphorylation at Ser ( 563 ) and Ser ( 660 ), the PKA regulatory sites, and Ser ( 565 ), the AMPK regulatory site ...
AMPK inhibited epinephrine induced
HSL activity in L6 myotubes and was associated with reduced HSL Ser ( 660 ) but not Ser ( 563 ) phosphorylation ... HSL activity was reduced in L6 myotubes expressing constitutively active AMPK, confirming the inhibitory
effects of
AMPK on
HSL activity ... Conversely, in 3T3-L1 adipocytes,
AMPK activation after epinephrine stimulation did not
prevent HSL activity or glycerol release, which coincided with maintenance of HSL Ser ( 660 ) phosphorylation