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CD80 — IFNG

Text-mined interactions from Literome

Liu et al., Scand J Immunol 1999 (Lupus Erythematosus, Systemic) : Interferon-gamma (IFN-gamma) increased both CD80 and CD86 expression on monocytes from both SLE patients and normal groups, albeit less significantly in the former than in the latter, i.e. CD80 : 142.84+/-65.99 % versus 226.08+/-78.90 %, P < 0.05 ; and CD86 : 72.55+/-74.23 % versus 153.99+/-94.14 %, P < 0.05, when expressed as percentage modulation ... We concluded that CD80 and CD86 were differentially expressed and modulated on monocytes and the defective IFN-gamma induced up-regulation of CD80 and CD86 expression on SLE monocytes might be a factor in the pathogenesis of SLE
Kooy et al., J Pathol 1999 (Carcinoma, Basal Cell...) : Interferon-gamma induced ICAM-1 and CD40 expression, complete lack of HLA-DR and CD80 ( B7.1 ), and inconsistent HLA-ABC expression in basal cell carcinoma : a possible role for interleukin-10 ?
Subauste et al., J Immunol 2000 : IL-12 independent IFN-gamma production required CD80/CD86-CD28 interaction and, to a lesser extent, CD40-CD40L signaling
Matsumura et al., Ann Rheum Dis 2001 (Lymphadenitis...) : Interferon gamma (IFNgamma) consistently up regulated levels of CD80 and CD86 ... Salivary ductal cells in patients with SS can express CD80 and CD86 costimulatory molecules in response to IFNgamma
Takahashi et al., Infect Immun 2001 : Together, our findings showed that SEB induced monocyte apoptosis is closely associated with the enrichment of CD80 ( + ) monocytes generated before IFN-gamma production, followed by up-regulation of CD80 by IFN-gamma , and that LPS has negative effects in both cases
Terrazzano et al., J Leukoc Biol 2002 : Differential involvement of CD40, CD80 , and major histocompatibility complex class I molecules in cytotoxicity induction and interferon-gamma production by human natural killer effectors
Tsunawaki et al., J Rheumatol 2002 (Sjogren's Syndrome) : Interferon-gamma (IFN-gamma) induced the cultured salivary gland epithelial cells to express HLA class I antigens, HLA-DR antigens, CD80, and ICAM-1, while tumor necrosis factor-alpha (TNF-alpha) induced the expression of HLA class I antigens, CD80 , CD86, and VCAM
Thomas et al., Cancer Immunol Immunother 2004 (Carcinoma, Squamous Cell...) : Conversely, the decrease in CD80 expression in progressor HNSCCs could be restored by IFN-gamma , a known inducer of CD80 expression ... These data strongly suggest that high levels of cytokines IL-1 alpha, IL-6, and GM-CSF expressed by tumor cells can down-regulate CD80 expression in HNSCC, and that IFN-gamma can independently stimulate expression
Rutkowski et al., Arch Immunol Ther Exp (Warsz) 2003 (Asthma) : CD80 and CD86 expression on LPS stimulated monocytes and the effect of CD80 and CD86 blockade on IL-4 and IFN-gamma production in nonatopic bronchial asthma
Blanchet et al., Am J Respir Crit Care Med 2004 (Alveolitis, Extrinsic Allergic) : To test the effect of nicotine on alveolar macrophages, AMJ2-C11 cells were treated with nicotine and stimulated with lipopolysaccharide or Saccharopolyspora rectivirgula, a causative agent of HP. Nicotine reduced tumor necrosis factor release and tumor necrosis factor, interleukin-10, and IFN-gamma mRNA expression after stimulation and decreased CD80 expression by 55 % in lipopolysaccharide stimulated cells and by 41 % in S. rectivirgula stimulated cells
Nakahara et al., Clin Exp Immunol 2005 (Neoplasms) : Our results show that IFN-gamma , but not IL-1beta, augmented the surface expression of CD80 , CD83 and CD86 molecules without inducing IL-12 production from DCs
Li et al., J Immunol 2006 (Glomerulonephritis) : Following i.p. immunization, CD86, but not CD80 , promotes early Ag-specific TCR-transgenic DO11.10 CD4+ cell proliferation and IFN-gamma production, suggesting that CD100 expression enables full expression of CD86 and consequent CD4+ cell activation
Wan et al., J Immunol 2006 (Arthritis, Rheumatoid) : The expression of CD80 and PD ligand-1 on monocytes could be induced in vitro by IFN-gamma and TNF-alpha that were produced abundantly in RA-derived synovial fluid ( SF )
Raykov et al., Int J Cancer 2008 : In this setup, which excludes direct oncolytic effects on metastases, the JabCG2 vector displayed enhanced immunogenicity, inducing markers of cellular immunity ( IFN gamma ) and dendritic cell activation ( CD80 , CD86 ) in mediastinal ( tumour draining ) lymph nodes
Steers et al., Vaccine 2008 : L ( LA ) enhanced the surface expression of MHC class I, class II, CD80 , and CD86 molecules, induced the secretion of IFN-gamma , IL-12p40, TNF-alpha and IL-10, and caused a shift in the proteasome profile from constitutive to immunoproteasomes as observed by the induction of beta2i, beta5i, PA28alpha, and PA28beta subunits
Nguyen et al., Cytotherapy 2008 : At a contaminating concentration of 5 Plt/MO, matured DC showed the highest expression of HLA-DR, CD80 and CD86, inducing a strong T-cell proliferation with high production of IL-4 and interferon-gamma
Pilon et al., Mol Immunol 2009 : We found that human CD40L induced DC maturation characterised by increased expression of co-stimulatory CD80/86 molecules, high production of IL-12p40 in DC and induction of IFNgamma and t-bet mRNA in T cells, suggesting a Th1 orientation
Izawa et al., Biochem Biophys Res Commun 2010 : Moreover, P-gp blockade, compared to controls, attenuated intragraft expression of CD3 and CD80 , but not CD86, and inhibited IFN-gamma and IL-4 production ( P < 0.05 )
Lanier et al., J Immunol 1995 (Mast-Cell Sarcoma) : When we used small, resting human peripheral blood T cells as responders, both CD80 and CD86 transfectants efficiently costimulated anti-CD3 mAb induced proliferation and the secretion of IL-2 and IFN-gamma
Barcy et al., Int Immunol 1995 : We have studied the expression of the CD80 ( B7-1 ) and B7-2 molecules on peripheral blood monocytes following different activation signals, and it was demonstrated that not only IFN-gamma , but also granulocyte macrophage colony stimulating factor can induce CD80 expression on monocytes
Petro et al., Immunol Invest 1995 : Production of IFN-gamma was significantly blocked by either anti-CD80 and anti-CD86
Ozawa et al., Eur J Immunol 1996 : Interferon-gamma and interleukin-10 inhibit antigen presentation by Langerhans cells for T helper type 1 cells by suppressing their CD80 ( B7-1 ) expression ... Based on the recently reported effect of interferon (IFN)-gamma and interleukin (IL-)-10 on the expression of CD80 and CD86 by LC, we examined the effects of these cytokines on the expression of CD54 ( intercellular adhesion molecule-1 ) and CD40 in addition to CD80 and CD86 on LC, and correlated the expression of each co-stimulatory molecule with antigen presentation for a Th1 clone by cultured LC (cLC) treated with these cytokines ... As previously reported, IL-10 or IFN-gamma inhibited the up-regulation of CD80 expression ... Granulocyte/macrophage-colony stimulating factor ( GM-CSF ) partially restored the suppression of CD80 expression induced by IFN-gamma on cultured LC, while it had virtually no effect on the inhibition induced by IL-10 ... The inhibitory effect of IFN-gamma on CD80 expression on LC appears to be partially mediated through the suppression of GM-CSF production by KC
Lando et al., J Immunol 1996 : Large amounts of IL-2, IFN-gamma , and TNF were produced in addition to an increase in IL-2 mRNA as a result of CD80 costimulation
Laihia et al., Arch Dermatol Res 1996 : CD80 expression was efficiently induced in monocytic ( CD14+ ) cells by human interferon-gamma , while CD28 levels on lymphocytes remained unchanged, as detected by flow cytometry
Saito et al., Eur J Immunol 1996 (Acute Disease...) : Furthermore, anti-CD80 + 86 mAb preferentially inhibited the production of interferon (IFN)-gamma , but not IL-4 and IL-10, when cultures were assayed at 21 days
Fleischer et al., Immunology 1996 : Inhibition studies using different antibodies against both molecules and the fusion protein CTLA4Ig show that only anti-CD80 and CTLA4Ig could partially inhibit antigen-specific ( tuberculin ) and polyclonal ( anti-CD3 ) lymphoproliferation and interferon-gamma (IFN-gamma) secretion of T cells cocultured with autologous monocytes
Yokozeki et al., Br J Dermatol 1997 : Interferon-gamma differentially regulates CD80 ( B7-1 ) and CD86 ( B7-2/B70 ) expression on human Langerhans cells ... These data indicate that the CD80 and CD86 expression of human LCs may be differently regulated by IFN-gamma
Subauste et al., J Immunol 1998 : Moreover, proliferation and IFN-gamma production by CD4+ CD45RA+ T cells from unexposed individuals were dependent on both CD80 and CD86