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IFNG — SOCS3

Pathways - manually collected, often from reviews:

• Reactome Reaction: IFNG → SOCS3 (indirect_complex) Yasukawa et al., EMBO J 1999*, Sasaki et al., Genes Cells 1999*
• Reactome Reaction: IFNG → SOCS3 (reaction) Yasukawa et al., EMBO J 1999*, Sasaki et al., Genes Cells 1999*

Text-mined interactions from Literome

Dogusan et al., J Neuroimmunol 2000 (Leukemia) : SOCS-3 expression was enhanced by PRL or by IFN-gamma
Cwikel et al., Exp Hematol 2001 : Interferon-gamma had no effect on CIS-3/JAB induction in these cells
Woldman et al., J Biol Chem 2001 : Suppressor of cytokine signaling 3 ( SOCS3 ) inhibited the activation of Stat5 by the IFN-gamma receptor, and the Tyr-440 containing peptide stretch was sufficient for repression
Karlsen et al., Proc Natl Acad Sci U S A 2001 : Whereas SOCS-3 mediated inhibition of IFN-gamma signaling is described in other cell systems, SOCS-3 mediated inhibition of IL-1beta signaling has not previously been described
Federici et al., J Immunol 2002 (Dermatitis, Allergic Contact...) : Suppressor of cytokine signaling (SOCS)1 and SOCS3 are negative regulators of IFN-gamma signaling and are induced in many cell types by IFN-gamma itself or by other cytokines ... We show in this work that SOCS1, SOCS2, SOCS3 , and cytokine-inducible SH2 containing protein mRNA were up-regulated by IFN-gamma in normal human keratinocytes, whereas only SOCS1 or SOCS1 and cytokine-inducible SH2 containing protein were induced by TNF-alpha or IL-4, respectively
Gatto et al., J Biol Chem 2004 : Accordingly, IFNgamma induced SOCS-3 protein expression was not impaired in STAT3-deficient embryonal fibroblasts ... Taken together, these results demonstrate that the induction of SOCS-3 by IFNgamma depends upon the presence of a STAT binding element in the SOCS-3 promoter that is specifically activated by STAT1
Ramana et al., Biochem Biophys Res Commun 2005 (Adenocarcinoma...) : Stat1 independent induction of SOCS-3 by interferon-gamma is mediated by sustained activation of Stat3 in mouse embryonic fibroblasts ... Tyrosine kinases Jak1 and Jak2 are required for SOCS-3 induction by IFN-gamma in mouse embryonic fibroblasts ... However, SU6656 inhibited IFN-gamma induction of SOCS-3 completely in Stat1-/- but not in wild-type fibroblasts ... Knock down of Stat3 by short interfering RNA abrogated Stat3 activation and SOCS-3 induction by IFN-gamma in Stat1-/- fibroblasts ... SOCS-3 induction by IFN-gamma is strictly Stat1 dependent ... The Stat1 docking site is required for SOCS-3 induction by IFN-gamma in human lung adenocarcinoma cells ... We propose a model in which sustained activation of Stat1 or Stat3 mediates SOCS-3 induction by IFN-gamma in wild-type and Stat1-/- mouse embryonic fibroblasts, respectively
Yao et al., J Virol 2005 : Silencing either SOCS1 or SOCS3 by small interfering RNA dramatically augments the production of IFN-gamma in T cells, thereby abrogating the inhibitory effect of core
Kovarik et al., Melanoma Res 2005 (Melanoma) : Interferon-gamma , but not interferon-alpha, induces SOCS 3 expression in human melanoma cell lines ... IFN-gamma induced SOCS 3 in 83 % of melanoma cell lines, whereas IFN-alpha stimulated SOCS 3 expression in only 11 % of cases ... Similarly, melanocytes showed strong induction of SOCS 3 by IFN-gamma and, to a lesser extent, by IFN-alpha
Dickensheets et al., Genes Immun 2007 : Unlike their common ability to induce expression of SOCS-1, IL-4 also induced expression of SOCS-2 but not SOCS-3 in macrophages, whereas IFN-gamma induced expression of SOCS-3 but not SOCS-2
Uchida et al., Eur J Immunol 2007 : Inhibition of SOCS3 by RNA interference up-regulated the phosphorylation of STAT3 and suppressed in vitro IL-4 production by IL-18 primed liver MNC stimulated with alpha-GalCer, but it did not affect IFN-gamma production
Parsa et al., Mol Immunol 2008 (Tularemia) : An analysis of the molecular mechanism of STAT1 inhibition indicated that expression of SOCS3 , an established negative regulator of IFNgamma signaling, is highly up-regulated during infection and suppresses STAT1 phosphorylation
McGillicuddy et al., J Biol Chem 2009 (Insulin Resistance) : IFNgamma induced robust STAT1 phosphorylation and SOCS1 mRNA expression, with modest, transient STAT3 phosphorylation and SOCS3 induction
Suzuki et al., Oncogene 1998 (Leukemia, Myeloid, Acute) : In M1 myeloid leukemia cells, CIS3 was induced by neither interleukin 6 (IL6) nor interferon gamma (IFNgamma) , while JAB was induced strongly by IFNgamma and slightly by IL6 and leukemia inhibitory factor (ILF)