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NOTCH3 — SKP2

Text-mined interactions from Literome

Sarmento et al., J Exp Med 2005 : Up-regulation of SKP2 by Notch signaling enhances proteasome mediated degradation of the CKIs, p27 Kip1 and p21 Cip1, and causes premature entry into S phase
Dohda et al., Exp Cell Res 2007 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : This suggests that other immediate Notch downstream genes are activated, and we found that Notch signaling controls the levels of expression of the E3 ubiquitin ligase SKP2 and its target protein p27Kip1