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CTGF — IL6

Text-mined interactions from Literome

Karger et al., Cell Signal 2008 : CTGF stimulated binding of NF-kappaB to the IL-6 promoter, and siRNA targeting the NF-kappaB subunit RelA interfered with CTGF induced IL-6 expression, implicating the NF-kappaB pathway in the mediation of the CTGF effect
Gressner et al., World J Gastroenterol 2011 (Fibrosis...) : To investigate the mechanisms involved in a possible modulator role of interleukin (IL)-6 signalling on CYR61-CTGF-NOV (CCN) 2/connective tissue growth factor (CTGF) expression in hepatocytes ( PC ) and to look for a relation between serum concentrations of these two parameters in patients with acute inflammation ... However, the STAT3 SH2 domain binding peptide, a selective inhibitor of STAT3 DNA binding activity, counteracted the inhibitory effect of IL-6 on CCN2/CTGF expression much more pronounced than pyrrolidine-dithiocarbamate, an inhibitor primarily of STAT3 phosphorylation
Liu et al., PloS one 2012 (MAP Kinase Signaling System) : OASFs showed significant expression of CTGF, and expression was higher than in normal SFs. OASFs stimulation with CTGF induced concentration dependent increases in IL-6 expression ... Our results suggest that CTGF increased IL-6 production in OASFs via the avß5 integrin, ASK1, p38/JNK, and AP-1/NF-?B signaling pathways
Wang et al., Mol Med Report 2013 : CTGF stimulation resulted in the significant production of IL-6 , IL-8, C-C motif ligand 2 (CCL2), CCL20, MMP-1 and MMP-3 in FLSs in the presence, but not in the absence, of IL-1ß