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EPHB2 — HSF1
Text-mined interactions from Literome
Dai et al., J Biol Chem 2000
:
We have previously shown that the mitogen activated protein kinase
ERK phosphorylates and
suppresses HSF-1-driven transcription
Melling et al., J Mol Cell Cardiol 2006
(MAP Kinase Signaling System) :
Given that ERK1/2 has been shown to be a negative regulator of HSF1 in vitro, these results suggest a
role for
ERK1/2 in the PKA mediated regulation of
HSF1 activation following exercise
Mivechi et al., Cancer Res 1995
:
Increases in
ERK1 activity through treatment of cells with sodium vanadate ( SV ), an inhibitor of the dual-specificity MAP kinase phosphatase 1 ( PAC1 ),
resulted in increased phosphorylation of the
heat shock transcription factor-1 ( HSF-1 ) in unheated cells, delayed the activation of HSF-1 by heat shock, and inhibited the induction of hsp 70 by heat shock ... Increases in
ERK1 activity through treatment of cells with sodium vanadate ( SV ), an inhibitor of the dual-specificity MAP kinase phosphatase 1 ( PAC1 ), resulted in increased phosphorylation of the heat shock transcription factor-1 ( HSF-1 ) in unheated cells,
delayed the activation of
HSF-1 by heat shock, and inhibited the induction of hsp 70 by heat shock