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EPHB2 — GDNF

Text-mined interactions from Literome

Honda et al., Neurosci Lett 1999 : Moreover, GDNF stimulated the phosphorylation of MAP kinase (ERK1/2) in the cells
You et al., Invest Ophthalmol Vis Sci 2000 : In epithelium, predominantly ERK 1 was activated by NGF, GDNF , and BDNF ... In stromal cells NGF and GDNF stimulated phosphorylation of ERK 1 and JNK 1 ... GDNF and NGF stimulate corneal epithelial proliferation, and the effect of the latter might be mediated by activation of ERK 1
Besset et al., J Biol Chem 2000 : Mutation of Tyr-1096 ( Y1096F ), a binding site for the adaptor Grb2, had no effect on Erk activation by GDNF
Focke et al., J Neurobiol 2001 : We found that GDNF stimulates the phosphorylation of both the PI 3-kinase downstream substrate Akt and the MAP kinase substrate ERK in cultures of immunoaffinity purified embryonic avian enteric crest derived cells ... The ERK kinase ( MEK ) inhibitors PD 98059 and UO126 did not reduce GDNF stimulated proliferation, although PD 98059 blocked GDNF stimulated phosphorylation of ERK
Coulpier et al., J Biol Chem 2002 : Protein transduction of anti-Tyr ( P ) ( 1062 ) antibodies into cultured cells reduced activation of MAPKs ERK1 and ERK2 and the AKT kinase in response to GDNF and diminished GDNF dependent neuronal differentiation and survival of embryonic sensory neurons from the nodose ganglion
Maeda et al., Biochem Biophys Res Commun 2004 : Expression of Gab1 PI3K-m in SK-N-MC human primitive neuroectodermal tumor cells expressing wild-type RET markedly impaired Akt phosphorylation, Rac1 activation, and lamellipodia formation that were induced by GDNF whereas expression of Gab1 SHP2-m partially impaired Erk activation
Coulpier et al., Mol Cell Neurosci 2004 : Retrograde signaling was associated with retrograde transport of radiolabeled GDNF and GFR alpha 1, as well as activation of RET and AKT, but not of ERK1/2 , in cell bodies
Galaria et al., J Surg Res 2005 : ATF mediated migration is PI3-K dependent and activates two separate pathways : ERK1/2 and akt ... ATF induces akt phosphorylation through a PI3K mediated but ras independent mechanism while both ras and PI3K are required for ERK1/2 activation
Hauck et al., Mol Cell Biol 2006 : We correlate the findings to intact porcine retina, where GDNF induces phosphorylation of ERK in the perinuclear region of RMG located in the inner nuclear layer
Hisaoka et al., J Pharmacol Exp Ther 2007 : The extent of acute ERK activation and GDNF release were significantly correlated to each other in individual antidepressants, suggesting an important role of acute ERK activation in GDNF production ... Taken together, these findings indicate that ERK activation through PTK regulates antidepressant induced GDNF production and that the GDNF production in glial cells may be a novel action of the antidepressant, which is independent of monoamine
Subramaniam et al., Cell Tissue Res 2008 : GDNF alone prevents low-potassium induced caspase-3 activation and DNA fragmentation but does not affect either low-potassium induced ERK activation or PM damage
Hisaoka et al., Nihon Shinkei Seishin Yakurigaku Zasshi 2007 : We reported that total GDNF levels in whole blood in patients with mood disorders were significantly lower than those in healthy control subjects ( Takebayashi et al, 2006 ), and antidepressants increased GDNF production through monoamine independent activation of protein tyrosine kinase ( PTK ) and extracellular signal regulated kinase ( ERK ) in glial cells ( Hisaoka et al, 2007 )
Lindgren et al., J Neurosci Res 2008 (Disease Models, Animal...) : GDNF caused an increase in the phosphorylation of ERK1/2 both in the striatum and in tyrosine hydroxylase positive neurons in the substantia nigra
Manfredsson et al., Mol Ther 2009 (Body Weight...) : However, only nigrostriatal GDNF overexpression induced activation of phosphorylated extracellular signal regulated kinase ( p-ERK ) in a small population of corticotrophin releasing factor [ corticotrophin releasing hormone (CRH) ] neurons located specifically in the medial parvocellullar division ( MPD ) of the paraventricular nucleus of the hypothalamus
Su et al., J Cell Physiol 2009 (Chondrosarcoma...) : Taken together, these results suggest that the GDNF acts through MEK/ERK , which in turn activates IKKalpha/beta and NF-kappaB, resulting in the activations of alphavbeta3 integrin and contributing the migration of human chondrosarcoma cells
Dinér et al., J Med Chem 2012 : Furthermore, 7a inhibited GDNF induced RET phosphorylation of ERK1/2 in MCF-7 breast cancer cells at concentrations as low as 100 nM
Lucas et al., Toxicology 2012 : Mono- ( 2-ethylhexyl ) -phthalate ( MEHP ) affects ERK dependent GDNF signalling in mouse stem-progenitor spermatogonia
Cavel et al., Cancer Res 2012 (Neoplasm Invasiveness...) : Genetic and pharmacologic inhibition of the GDNF receptors GFRA1 and RET abrogated the migratory effect of EMF-CM and reduced ERK phosphorylation
Euteneuer et al., Mol Cell Neurosci 2013 (MAP Kinase Signaling System) : GDNF/GFRa1-Fc stimulation activates intracellular PI3K/Akt and MEK/Erk signaling cascades as detected by Western blot analysis of cultures prepared from rats at postnatal days 5 ( P5, before the onset of hearing ) and 20 ( P20, after the onset of hearing )
Lin et al., PloS one 2013 (Hyperglycemia...) : EGR-1 siRNA also reduced GDNF/EGR-1 induced cRaf/MEK/ERK phosphorylation by 80 %
Nguyen et al., J Biol Chem 1998 : The amino-terminal fragment (ATF) of uPA, which binds to uPAR but lacks proteinase activity, also activated ERK1 and ERK2