◀ Back to IL1A

IL1A — MSH6

Text-mined interactions from Literome

Birchall et al., Biochem Biophys Res Commun 1991 (Carcinoma, Squamous Cell...) : The following points were established : 1 ) both cell lines produced IL-1 and their production was stimulated by exposure of the cells to UV ; 2 ) both cell lines possessed high affinity binding sites for MSH, and their ability to bind MSH was modulated by IL-1; 3 ) IL-1 exhibited both stimulatory and inhibitory effects on MSH binding to Cloudman cells ; and 4 ) the stimulatory effect of IL-1 on MSH binding to melanoma cells was reflected in enhanced cellular responsiveness to MSH regarding tyrosinase activity ( E.C. 1.14.18.1 ) and melanin content
Mason et al., J Immunol 1989 : The direct injection of MSH, beta-endorphin and ACTH into sponges or i.p. did not stimulate a neutrophil emigration and eliminated the possibility that MSH or ACTH suppressed the neutrophil influx in response to IL-1 , TNF, or C5a by competing for circulating neutrophils
Cannon et al., J Immunol 1986 : IL 1-induced production of prostaglandin E ( PGE ) by fibroblasts was also inhibited by alpha MSH with a biphasic dose response ... The minimal effective concentration was 10 ( -11 ) M, and maximum effect was achieved at 10 ( -10 ) M. alpha MSH appeared to affect the interaction of IL 1 with its target cells in a specific manner, because it did not inhibit basal mitogen induced thymocyte proliferation or IL 2-induced proliferation of a cytotoxic T lymphocyte line ... Furthermore, production of IL 1 by endotoxin stimulated monocytes was not affected by alpha MSH