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CHEK2 — TP53

Pathways - manually collected, often from reviews:

• BioCarta cell cycle: g2/m checkpoint: CHK2 (CHEK2) → p53/MDM2 complex (TP53-MDM2) (modification, activates)
  
• BioCarta cell cycle: g2/m checkpoint: CHK2 (CHEK2) → p53 (TP53) (modification, activates)
• BioCarta regulation of cell cycle progression by plk3: CHK2 (CHEK2) → p53 (TP53) (modification, activates)
• KEGG Cell cycle: CHEK1/CHEK2 → TP53 (protein-protein, phosphorylation)
• KEGG p53 signaling pathway: CHEK2 → TP53 (protein-protein, activation)
• WikiPathways Cell Cycle: CHEK1/CHEK2 → TP53 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: TP53 — CHEK2 (experimental interaction detection) Bjørling-Poulsen et al., Oncogene 2005*
• IRef Biogrid Interaction: CHEK2 — TP53 (direct interaction, enzymatic study) Adams et al., EMBO Rep 2008*
• IRef Biogrid Interaction: CHEK2 — TP53 (direct interaction, enzymatic study) Hirao et al., Science 2000*
• IRef Biogrid Interaction: CHEK2 — TP53 (direct interaction, enzymatic study) Bjørling-Poulsen et al., FEBS Lett 2005*
• IRef Biogrid Interaction: CHEK2 — TP53 (direct interaction, enzymatic study) Shieh et al., Genes Dev 2000*
• IRef Biogrid Interaction: CHEK2 — TP53 (physical association, affinity chromatography technology) Louria-Hayon et al., J Biol Chem 2003*
• IRef Hprd Interaction: TP53 — CHEK2 (in vitro) Bruno et al., Cancer Cell 2006*
• IRef Intact Interaction: CHEK2 — TP53 (phosphorylation reaction, protein kinase assay) Adams et al., EMBO Rep 2008*
• IRef Intact Interaction: CHEK2 — TP53 (phosphorylation reaction, experimental interaction detection) Lee et al., Nature 2000*
• IRef Intact Interaction: CHEK2 — TP53 (phosphorylation reaction, experimental interaction detection) Bjørling-Poulsen et al., FEBS Lett 2005*

Text-mined interactions from Literome

Tominaga et al., J Biol Chem 1999 : In addition, transfection of normal human fibroblasts with SV40 T antigen or human papilloma viruses E6 or E7 causes a marked induction of hCds1 mRNA, and the introduction of functional p53 into SV40 T antigen- and E6-, but not E7-, transfected cells decreases the hCds1 level, suggesting that p53 negatively regulates the expression of hCds1
Dong et al., Am J Hum Genet 2003 (Prostatic Neoplasms) : In this study, we analyzed CHEK2 , the upstream regulator of p53 in the DNA-damage signaling pathway, in several groups of patients with prostate cancer
Ahn et al., J Biol Chem 2003 (Colonic Neoplasms) : Questioning the role of checkpoint kinase 2 in the p53 DNA damage response
Chin et al., Exp Mol Pathol 2003 : Tissue-specific regulation of checkpoint kinase 2 expression by p53
Spurlock et al., Arthritis Rheum 2012 (Arthritis, Rheumatoid...) : In tissue culture, MTX induced expression of both p53 and p21 by JNK-2- and JNK-1 dependent mechanisms, respectively, while CHEK2 and RANGAP1 were not induced by MTX