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RPA1 — TP53
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
RPA1
—
TP53
(direct interaction, pull down)
Romanova et al., Oncogene 2004*
-
IRef Biogrid Interaction:
RPA1
—
TP53
(physical association, affinity chromatography technology)
Romanova et al., Oncogene 2004*
-
IRef Biogrid Interaction:
RPA1
—
TP53
(physical association, affinity chromatography technology)
Riva et al., Carcinogenesis 2001*
-
IRef Dip Interaction:
RPA1
—
TP53
(physical association, affinity chromatography technology)
Lin et al., J Biol Chem 1996*
-
IRef Hprd Interaction:
TP53
—
RPA1
(in vitro)
Riva et al., Carcinogenesis 2001*, Romanova et al., Oncogene 2004*, Sommers et al., Cancer Res 2005*, Dutta et al., Nature 1993*
-
IRef Hprd Interaction:
TP53
—
RPA1
(in vivo)
Riva et al., Carcinogenesis 2001*, Romanova et al., Oncogene 2004*, Sommers et al., Cancer Res 2005*, Dutta et al., Nature 1993*
-
IRef Intact Interaction:
RPA1
—
TP53
(physical association, enzyme linked immunosorbent assay)
Sommers et al., Cancer Res 2005*
Text-mined interactions from Literome
Ljungman et al., Cell cycle (Georgetown, Tex.) 2007
:
Recently, it was shown that the ATR kinase and the single-strand DNA binding protein
RPA mediate the phosphorylation of
p53 following blockage of transcription elongation
Leiter et al., Oncogene 1996
:
The tumor suppressor protein
p53 activates transcription from promoters with specific p53 binding elements, represses transcription from promoters without such elements and interacts with and inhibits the single stranded DNA binding activity of the human DNA replication factor
RPA