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CCND1 — NFKB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Hinz et al., Mol Cell Biol 1999
:
Moreover, inhibition of
NF-kappaB caused a pronounced reduction of serum induced
cyclin D1-associated kinase activity and resulted in delayed phosphorylation of the retinoblastoma protein
Guttridge et al., Mol Cell Biol 1999
(Cell Transformation, Neoplastic) :
An analysis of cell cycle markers revealed that
NF-kappaB activates
cyclin D1 expression, and the results showed that this regulatory pathway is one mechanism by which NF-kappaB inhibits myogenesis ... NF-kappaB regulation of
cyclin D1 occurs at the transcriptional level and is
mediated by direct binding of
NF-kappaB to multiple sites in the cyclin D1 promoter ... Using diploid fibroblasts, we demonstrate that
NF-kappaB is
required to induce
cyclin D1 expression and pRb hyperphosphorylation and promote G ( 1 ) -to-S progression
Whitehead et al., Mol Cell Biol 1999
(Cell Transformation, Neoplastic) :
Finally, we have observed that Dbl and Dbs regulated transcription from the
cyclin D1 promoter in a
NF-kappaB dependent manner
Henry et al., Mol Cell Biol 2000
:
Here we show that expression of activated Ral in quiescent rodent fibroblasts is sufficient to induce activation of
NF-kappaB dependent gene expression and
cyclin D1 transcription, two key convergence points for mitogenic and survival signaling ... The regulation of
cyclin D1 transcription by Ral is
dependent on
NF-kappaB activation and is mediated through an NF-kappaB binding site in the cyclin D1 promoter
Mori et al., Int J Cancer 2002
(Leukemia, T-Cell) :
Inhibitors of
NF-kappaB ( dominant negative IkappaBs mutants )
suppressed Tax dependent activation of
cyclin D1 and D2 promoters, indicating that Tax induced activation was mediated by NF-kappaB
Ashikawa et al., J Immunol 2002
:
Piceatannol abrogated the expression of TNF induced
NF-kappaB dependent reporter gene and of matrix metalloprotease-9, cyclooxygenase-2, and
cyclin D1
Shishodia et al., Carcinogenesis 2003
(Carcinoma, Non-Small-Cell Lung...) :
The inhibition of NF-kappaB activation correlated with suppression of CS-induced
NF-kappaB dependent
cyclin D1 , cyclooxygenase-2 and matrix metalloproteinase-9 expression
Rocha et al., Mol Cell Biol 2003
:
p53 represses
cyclin D1 transcription through down regulation of Bcl-3 and
inducing increased association of the p52
NF-kappaB subunit with histone deacetylase 1
Shishodia et al., Cancer Res 2003
:
The inhibition of NF-kappaB activation correlated with suppression of
NF-kappaB dependent
cyclin D1 , cyclooxygenase 2, and matrix metalloproteinase 9 expression
Shukla et al., Neoplasia (New York, N.Y.) 2004
(Adenocarcinoma...) :
The nuclear levels of NF-kappaB/p65 correlated with concurrent increase in cytosolic levels of IkappaBalpha along with
NF-kappaB dependent expression of Bcl2,
cyclin D1 , MMP-9, and VEGF
Fernandez-Zapico et al., Cancer Cell 2005
(Adenocarcinoma...) :
Mechanistically, the effects of Vav1 require its GEF activity and the activation of Rac1, PAK1, and
NF-kappaB and
involve cyclin D1 upregulation
Preciado et al., J Immunol 2005
:
As one potential mechanism for this increase in proliferation, an
NF-kappaB-specific activation of
cyclin D1 was observed
Hu et al., Mol Cancer Res 2005
:
Trichostatin A inhibits
cyclin D1 expression in a
NF-kappaB dependent manner in JB6 cells
Häussler et al., American journal of physiology. Renal physiology 2005
:
We provide evidence for a direct link between EGF,
nuclear factor-kappaB (NF-kappaB) , and cell cycle
regulation (
cyclin D1 ) ... Moreover, inhibition of
NF-kappaB caused a pronounced reduction of EGF induced
cyclin D1 promoter activity
Ho et al., Toxicol Appl Pharmacol 2005
(Lung Neoplasms) :
To determine whether the NNK induced
NFkappaB activation and
cyclin D1 induction were also observed in vivo, A/J mice were treated with NNK ( 9.1 mg ) for 20 weeks and the results showed a significant induction of cyclin D1 and NFkappaB translocation determined by immunoblotting analyses
Ouyang et al., Cancer Res 2005
:
The induction of
cyclin D1 by arsenite
required nuclear factor-kappaB (NF-kappaB) activation, because the inhibition of IkappaB phosphorylation by overexpression of the dominant negative mutant, IKKbeta-KM, impaired arsenite induced cyclin D1 expression and G1-S transition
Devi et al., Eur J Pharmacol 2005
(Diabetes Mellitus, Experimental...) :
Administration of 300 mg thioacetamide/kg to diabetic rats inhibited
NF-kappaB regulated
cyclin D1 signaling, explaining inhibited tissue repair, liver failure and death, whereas remarkably higher NF-kappaB-DNA binding but transient down regulation of cyclin D1 expression explains delayed tissue repair in the diabetic rats receiving 30 mg thioacetamide/kg
Morante et al., Free radical research 2005
(Body Weight...) :
Moreover, chromatin immunoprecipitation ( ChIP ) assay demonstrated that
NF-kappaB directly
regulates transcription of gamma-GCS ( both subunits ) and
cyclin D1 through the binding of NF-kappaB to the corresponding gene promoters, which was enhanced in vitamin E-deficiency
Corbetta et al., Endocr Relat Cancer 2005
(Parathyroid Neoplasms) :
Although TNFalpha was poorly effective in increasing cyclin D1 expression,
NF-kappaB blockade by the specific inhibitor BAY11-7082
reduced FCS stimulated
cyclin D1 by about 60 %
Rubio et al., Oncogene 2006
(Breast Neoplasms...) :
We have found that TNF-alpha exerts a mitogenic effect, inducing
cyclin D1 expression and
activation of the transcription factor
NF-kappaB ... Importantly, activation of
NF-kappaB was
required for estrogen induced proliferation and
cyclin D1 expression
Schmidt-Ullrich et al., Development 2006
:
We show that
NF-kappaB activation is
essential for induction of Shh and
cyclin D1 expression and subsequent placode down growth
Chang et al., Cell Microbiol 2006
(Helicobacter Infections) :
AP1 and cAMP response element ( CRE ), but not
NF-kappaB , were
involved in the induced
cyclin D1 expression
Park et al., J Biol Chem 2006
(Carcinoma, Hepatocellular...) :
Up-regulation of
cyclin D1 by HBx is
mediated by
NF-kappaB2/BCL3 complex through kappaB site of cyclin D1 promoter ... Here we show that HBx up-regulates
cyclin D1 and that this process is
mediated by the
NF-kappaB2 ( p52 ) /BCL-3 complex
Kuo et al., Cancer Lett 2007
(Breast Neoplasms) :
Furthermore, rugosin E also inhibited the TNF-alpha activated
NF-kappaB dependent reporter gene expression of
cyclin D1 , c-Myc, XIAP, Bcl-2, and Bcl-X ( L ) were all downregulated by rugosin E
Zhang et al., Endocrinology 2007
:
To further understand the mechanism of TNF stimulated growth of primary MEC, the requirement for
NFkappaB1/p50 , and the
role of
cyclin D1 in TNF stimulated growth were examined
Ozeki et al., J Neurosci Res 2007
:
Truncation of the NF-kappaB binding site in the cyclin D1 promoter fully abrogated the transcription of cyclin D1, suggesting that the
cyclin D1 transcription is
dependent on
NF-kappaB
Liang et al., J Neurosci Res 2007
:
These findings suggest that
NF-kappaB activation
stimulates cyclin D1 expression and triggers DNA replication in striatal neurons
Kunnumakkara et al., Cancer Res 2007
(Neovascularization, Pathologic...) :
In vivo, tumors from nude mice injected with pancreatic cancer cells and treated with a combination of curcumin and gemcitabine showed significant reductions in volume ( P = 0.008 versus control ; P = 0.036 versus gemcitabine alone ), Ki-67 proliferation index ( P = 0.030 versus control ),
NF-kappaB activation , and expression of NF-kappaB regulated gene products (
cyclin D1 , c-myc, Bcl-2, Bcl-xL, cellular inhibitor of apoptosis protein-1, cyclooxygenase-2, matrix metalloproteinase, and vascular endothelial growth factor ) compared with tumors from control mice treated with olive oil only
Sandur et al., Carcinogenesis 2007
:
The suppression of NF-kappaB activity correlated with inhibition of NF-kappaB reporter activity and with down-regulation of cyclooxygenase-2,
cyclin D1 and vascular endothelial growth factor, all
regulated by
NF-kappaB
Yao et al., Oral Dis 2007
(Tongue Neoplasms) :
Furthermore, L-685,458 down-regulated
cyclin D1 , B-cell lymphocytic-leukemia proto-oncogene 2 and c-Myc expressions, which are
regulated by the transcription factor
NF-kappaB
Lee et al., American journal of physiology. Renal physiology 2008
:
Consequently, the inhibition of Ca ( 2+ ), PKC, EGFR, p44/42 MAPKs, or
NF-kappaB blocked the BSA induced increases in
cyclin D1 , cyclin dependent kinase (CDK)4, cyclin E, or CDK2 and restored the BSA induced inhibition of p21 ( WAF/Cip1 ) and p27 ( Kip1 ) expression
Liu et al., Cancer Sci 2008
(Breast Neoplasms) :
Furthermore, we found that daintain/AIF-1 overexpression up-regulated the expression of cyclin D1 and enhanced the transcriptional activity of
nuclear factor-kappa B (NF-kappaB) , a
regulator of
cyclin D1 expression ... In contrast, the down-regulation of daintain/AIF-1 expression decreased
cyclin D1 expression and
inhibited the transcriptional activity of
NF-kappaB
Zhou et al., Mol Carcinog 2009
(Esophageal Neoplasms...) :
In this article, we found that Degenerative Spermatocyte Homolog 1 ( DEGS1 ) up-regulated the expression of cyclin D1 and the activation of transcription factor
NF-kappaB was
essential for DEGS1 induced
cyclin D1 production
Kim et al., Arch Pharm Res 2009
(Colonic Neoplasms) :
NF-kappaB target gene expression of apoptotic cell death proteins ( Bax, caspase-3, caspase-9 ) was significantly enhanced, but the expression of anti-apoptotic genes and cell proliferation marker genes ( Bcl-2, inhibitor of apoptosis protein ( IAP-1 ) and X chromosome IAP (XIAP), Cox-2, c-Fos, c-Jun and
cyclin D1 ) was significantly
inhibited by the combined treatment compared to Rg3 or docetaxel alone
Wang et al., Int J Cancer 2010
(Cell Transformation, Neoplastic...) :
This was associated with significantly lower proliferating cell nuclear antigen positive hepatocytes and
cyclinD1 protein, as well as decreased
activation of extracellular signal regulated kinase and nuclear
NF-kappaB
Guo et al., Biochim Biophys Acta 2009
:
Here, we report that
NF-kappaB site
mediated cyclin D1 transcription is inhibited by heat shock
Li et al., Int J Mol Med 2010
:
Pre-treatment of NS3 protein expressing cells with ERK inhibitor, PD98059, blocked the activation of AP-1 and
NF-kappaB , and
inhibited cyclin D1 expression and cell proliferation