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MMP1 — TP53

Text-mined interactions from Literome

Sun et al., Mol Carcinog 1999 (Neoplasm Metastasis) : p53 transcriptionally activates expression of the genes encoding epidermal growth factor receptor, matrix metalloproteinase (MMP)-2 , cathepsin D, and thrombospondin-1 but represses expression of the genes encoding basic fibroblast growth factor and multidrug resistance-1
Ala-aho et al., Oncogene 2002 (Carcinoma, Squamous Cell...) : These results show, that wild-type p53 potently inhibits expression of MMP-13 and MMP-1 by SCC cells independently of its pro-apoptotic effect
Sun et al., J Cell Biochem 2004 : We also demonstrate that both p300 and TATA box binding proteins cooperated with the transcription factor AP-1 to induce the promoter of MMP1 ; however, p53 only inhibited the p300 mediated induction of the MMP1 promoter and the inhibition was -72AP-1 dependent
Kim et al., Exp Dermatol 2008 : Basal and UV-induced MMP-1 expression are inhibited by p53 in human dermal fibroblasts ... However, little is known about the role of p53 on MMP-1 expression in human skin ... Here, we investigated the effects of p53 on basal and UV-induced MMP-1 in human dermal fibroblasts ... To verify the role of p53 on MMP-1 expression, adenoviral p53 ( Ad-p53 ) gene was infected to human dermal fibroblasts ... Our results showed that basal and UV-induced MMP-1 expression was prevented by Ad-p53 ... In contrast, p53 inhibitor, pifithrin-alpha augmented the UV-induced MMP-1 expression ... Taken together, we suggest that p53 inhibits basal and UV-induced MMP-1 expression in human dermal fibroblasts
Xiao et al., J Cell Biochem 2009 (Melanoma) : Cytoprotective effects of the lipoidic-liquiform pro-vitamin C tetra-isopalmitoyl-ascorbate ( VC-IP ) against ultraviolet-A ray induced injuries in human skin cells together with collagen retention, MMP inhibition and p53 gene repression
Kim et al., PloS one 2009 : Suppression of p300 histone acetyltransferase (p300HAT) activity by the p300HAT inhibitor anacardic acid ( AA ) or by down-regulation of p300 by siRNA prevented UV-induced MMP-1 expression and inhibited UV-enhanced gamma-H2AX, p53 level, and acetyl-H3
Wu et al., Cancer Res 2010 (Adenocarcinoma...) : In addition, in lung cancer cells and xenograft tumors in nude mice, overexpression of XPC suppresses cell/tumor metastatic ability via repression of matrix metalloproteinase-1 (MMP1) transcription by p53