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CDK5 — JUN
Text-mined interactions from Literome
Honjyo et al., Neuroreport 1999
:
Cdk5 requires either
p39 or p35 to assume its active form in the mammalian CNS
Liu et al., Neurobiol Aging 2009
:
Inhibition of proteasome resulted in activation of cAMP dependent protein kinase, glycogen synthase kinases-3beta and
cyclin dependent kinase-5 , and
inhibition of protein phosphatase-2A and
c-Jun N-terminal kinase (JNK)
Sun et al., Mol Biol Cell 2009
(Alzheimer Disease) :
In the second phase,
Cdk5 activates
c-Jun via ROS mediated activation of JNK
Chang et al., J Neurochem 2010
(Alzheimer Disease) :
Importantly,
Cdk5 mediated p38 activation
increases c-Jun expression, thereby revealing a mechanistic link between deregulated Cdk5 and c-Jun level in AD brains
Jalili et al., J Natl Cancer Inst 2012
(MAP Kinase Signaling System...) :
Using a dominant negative approach, in vitro cell proliferation assays, western blots, and flow cytometry showed that MAPK signaling via BRAF ( V600E ) promotes melanoma cell proliferation at G1 through
AP-1 mediated negative regulation of the INK4 family member,
cyclin dependent kinase inhibitor 2C ( CDKN2C ), and the CIP/KIP family member, cyclin dependent kinase inhibitor 1A ( CDKN1A )