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PLCG2 — VEGFA

Text-mined interactions from Literome

Bernatchez et al., Br J Pharmacol 2001 : 2. Using specific inhibitors and Western blot analysis, we herein report that in bovine aortic endothelial cells ( BAEC ), VEGF induces the synthesis of PAF through the cascade activation of Flk-1 receptor, phospholipase Cgamma ( PLCgamma ) , protein kinase C ( PKC ) and p42/44 mitogen activated protein kinases ( MAPK )
Ito et al., Angiogenesis 1999 : In accordance, VEGF induced tyrosine phosphorylation of phospholipase Cgamma ( PLCgamma ) and DNA synthesis were augmented by heparin
Sakurai et al., Proc Natl Acad Sci U S A 2005 : Recently, we showed that, among tyrosine residues of KDR, tyrosine residues 1175 ( Y1175, corresponding to Y1173 in murine Flk-1 ) and Y1214 ( Y1212 in Flk-1 ) are autophosphorylated in response to VEGF, and that Y1175 is important for VEGF dependent phospholipase Cgamma/PKC/mitogen activated protein kinase activation leading to DNA synthesis in cultured endothelial cells