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IGF2 — MMP9

Text-mined interactions from Literome

Bredin et al., Anticancer Res 2003 (Carcinoma, Non-Small-Cell Lung...) : IGF I, IGF II, HGF and EGF stimulated an enhanced expression and activity of the latent form of MMP-2 and MMP-9
Hills et al., J Endocrinol 2004 : IGF-II increased cell numbers 3.5-fold after 96 h in culture, and IGF-I had less effect ( 1.5-fold increase ) ( both P < 0.05 ). IGF-II also had a greater effect on the levels of matrix metalloproteinase (MMP)-2 and MMP-9. Phosphorylated and non phosphorylated iso-forms of IGFBP-1 added alone increased cell numbers and MMP levels ( P < 0.05 ). IGFBP-1 did not modify the effects of IGF-II on cell numbers or on MMP production. Term VCT numbers and MMP production in vitro were unaffected by IGFs ( P > 0.05 )
Rorive et al., Glia 2008 (Astrocytoma...) : Our results show the following : ( i ) MMP-9 proteolyzes the IGFBP2-IGFII complex in vitro, while MMP-2 and MT1-MMP do not ; ( ii ) this MMP-9 induced IGFBP2-IGFII complex proteolysis releases free IGFII, which contributes to enhance the motility and the growth of LN229 astrocytoma cells
Wirtz et al., Invest Ophthalmol Vis Sci 1998 : IGF-I, but not IGF-II , modestly increased trabecular stromelysin and gelatinase B but not collagenase, gelatinase A, or tissue inhibitor of metalloproteinases 1 or 2