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IFNG — TAP1

Text-mined interactions from Literome

Lee et al., Cancer Res 2000 (Neoplasm Metastasis...) : IFN-gamma induced surface class I MHC expression, as well as gene expression of TAP-1 , TAP-2, LMP-2, and LMP-7 in the metastatic cells, yet the cells remained resistant to cell lysis induced by CTLs. Interestingly, although in comparison to the primary cells the metastatic cells were resistant to cytolysis, both cell types were susceptible to DNA fragmentation induced by CTLs. Cell fusion between primary and metastatic cancer cells resulted in hybrids that also resisted the cytolytic activity of CTLs
Cramer et al., J Immunol 2000 : Synergistic induction of the Tap-1 gene by IFN-gamma and lipopolysaccharide in macrophages is regulated by STAT1
Tahara et al., Int J Oncol 2000 : IFN-gamma treatment induced the TAP-1 and LMP-2 genes, continuously up-regulated the HLA class I expression and increased cytolysis
Dovhey et al., Cancer Res 2000 (Carcinoma, Renal Cell...) : Loss of interferon-gamma inducibility of TAP1 and LMP2 in a renal cell carcinoma cell line ... The effects of IFN-gamma on TAP1 and LMP2 expression revealed a loss of up-regulation in Caki-2 cells, but not in Caki-1 cells
Mahboubi et al., J Biol Chem 2002 : Only IFN gamma increases TAP1 transcription assessed by reporter gene assay
Qin et al., Cancer Res 2002 (Neoplasms, Experimental) : In mixed tumor/lymphocyte culture, TAP1 expression by tumor cells significantly increased the IFN-gamma production of antigen-specific spleen cells from immunized, but not from naive, mice
Cecil et al., J Leukoc Biol 2004 : p38 activation through Toll-like receptors modulates IFN-gamma induced expression of the Tap-1 gene only in macrophages
Brucet et al., Genes Immun 2004 : Regulation of murine Tap1 and Lmp2 genes in macrophages by interferon gamma is mediated by STAT1 and IRF-1 ... In murine bone marrow derived macrophages, interferon gamma (IFN-gamma) induced Tap-1 and upregulated Lmp-2, which is constitutively expressed at low levels ... In macrophages from STAT1 knockout mice, IFN-gamma did not induce the expression of Tap-1 or Lmp-2 ... By making deletions of the promoter, we found that only the proximal GAS and IRF-1 boxes are required for IFN-gamma induction of Tap-1 and Lmp-2 ... These results indicate that both STAT1 and IRF-1 are required for the IFN-gamma induction of Tap-1 and Lmp-2 genes
Rouyez et al., J Immunol 2005 : In this study we report that IFN-gamma and thrombopoietin (TPO) strongly increase TAP1 protein expression in megakaryocytes, followed by an enhanced expression of MHC ( I ) on the cell surface ... Overall, our data indicate that TPO and IFN-gamma activate the expression of TAP1 via a new mechanism that involves functional cooperation between STAT1 and IRF-2 on the TAP1 promoter
Hayashi et al., Oncogene 2006 (Leiomyoma...) : The mutation in the ATP binding region of JAK1, identified in human uterine leiomyosarcomas, results in defective interferon-gamma inducibility of TAP1 and LMP2 ... The TAP1 and LMP2 genes are transcribed from a shared bidirectional promoter containing an interferon (IFN)-gamma-response factor element ; thus, the IFN-gamma-signal strongly induces both TAP1 and LMP2 expression
Kuroda et al., Immunology 1995 (Fibrosarcoma) : Interferon-gamma (IFN-gamma) treatment of these cells induced expression of Kk, TAP1 and TAP2 genes and rescued the defect of class I-restricted antigen presentation in 4C2 and 6D1 cells
Min et al., J Immunol 1996 : Kinetically coordinated induction of TAP1 and HLA class I by IFN-gamma : the rapid induction of TAP1 by IFN-gamma is mediated by Stat1 alpha ... Transporter associated with Ag processing-1 ( TAP1 ) is induced by IFN-gamma more rapidly than is HLA class I. Kinetic analysis of transfectants reveals that IFN-gamma activates the TAP1 promoter more rapidly than the HLA-B7 class I promoter
Fujimaki et al., Neuroreport 1996 : Expression of Tap-1 and Lmp-2 genes, which are involved in antigen processing and presentation, was also induced by IFN-gamma treatment
Cramer et al., Cell Immunol 1997 (Leukemia, Monocytic, Acute) : Stimulation of the human macrophage cell line THP-1 with interferon-gamma (IFN-gamma) resulted in maximal induction of both Tap-1 and Tap-2 mRNA within 24 hr. Nuclear run-on analyses showed that the increased expression of Tap-1 and Tap-2 was controlled at the level of transcription
Sospedra et al., Clin Exp Immunol 1997 : Results from immunofluorescence and Northern blotting studies on primary thyrocyte cultures and on a thyroid cell line demonstrate that thyrocytes express constitutively TAP-1 at a low level, and that this expression is readily induced by interferon-gamma (IFN-gamma) and to a lesser extent by IFN-alpha
Seliger et al., Clin Cancer Res 1997 (Carcinoma, Renal Cell...) : Analysis of the dual TAP-1/LMP-2 promoter activity revealed that TAP-1 and LMP-2 expression are controlled by IFN-gamma at the transcriptional level ... Thus, the IFN-gamma mediated coordinated transcriptional up-regulation of TAP-1 and LMP-2 expression occurs through the use of a common regulatory element, which might result in enhanced recognition of renal cell carcinoma cells by the immune system