Gene interactions and pathways from curated databases and text-mining

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DPP7 — INS

Text-mined interactions from Literome

Hollander et al., Postgrad Med 2010 (Cardiovascular Diseases...) : By enhancing and prolonging incretin effects, DPP-4 inhibitors stimulate glucose dependent insulin secretion and also reduce glucagon secretion
Wang et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2013 : In recent years, studies have revealed many possible mechanisms through which DPP-4 inhibitors regulate glycemia : DPP-4 inhibitors may selectively reduce DPP-4 activity in the intestine, causing the increase of portal plasma GLP-1 level and thus promoting the release of insulin via nerve reflex ; also, they may decrease the cleavage product of GLP-1 and reduce the degradation of other bioactive peptides