Gene interactions and pathways from curated databases and text-mining

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GDNF — INS

Text-mined interactions from Literome

Ban et al., Diabetes 2000 : Furthermore, when transfected into rat primary cultured islets, ATF-2 enhanced glucose induced insulin promoter activity, whereas cAMP response element binding protein ( CREB ) repressed it
Zmuda et al., Mol Endocrinol 2010 (Diabetes Mellitus, Type 2) : However, ATF3 deficiency significantly reduced serum insulin levels in the KO mice without affecting insulin sensitivity, suggesting reduced beta-cell function in the KO mice