◀ Back to INS

INS — TAS2R13

Text-mined interactions from Literome

Du et al., Science 2003 (Diabetes Mellitus...) : TRB3 expression is induced in liver under fasting conditions, and TRB3 disrupts insulin signaling by binding directly to Akt and blocking activation of the kinase
Prudente et al., Diabetes 2005 (Cardiovascular Diseases...) : TRB3 , a mammalian tribbles homolog, whose chromosomal region 20p13-p12 has been linked to human type 2 diabetes, impairs insulin signaling through the inhibition of Akt phosphorylation and is overexpressed in murine models of insulin resistance
Mortensen et al., Am J Physiol Endocrinol Metab 2006 : PGC-1alpha or PGC-1beta overexpression upregulated GLUT4 mRNA and downregulated myocyte enhancer factor 2C transcription factor mRNA ; only PGC-1alpha overexpression caused an increase in the mRNA expression of TRB3 , a negative regulator of insulin signaling
Yacoub Wasef et al., Am J Physiol Endocrinol Metab 2006 : We studied the regulation of TRB3 by glucose, insulin , dexamethasone ( Dex ), and the unfolded protein response ( UPR ) in 3T3-L1 adipocytes and in L6 myotubes
Koh et al., Mol Cell Biol 2006 (Insulin Resistance) : MLKB1KO mice had increased insulin stimulated Akt phosphorylation and a > 80 % decrease in muscle expression of TRB3 , a recently identified Akt inhibitor
Ding et al., Exp Cell Res 2008 : TRB3 negatively regulates Akt activation and noticeably, TRB3 expression is induced by insulin ... We find that insulin induces TRB3 expression in cell type dependent manner such that in hepatic cells and adipocytes but not Beta cells and muscle cells ... In Fao hepatoma cells, induction of TRB3 expression by insulin restrains Akt activation and renders Akt refractory to further activation ... Induction of TRB3 expression by insulin requires PI3K ... However, inactivation of Akt enhances TRB3 expression whereas inhibition of PKCzeta expression impairs TRB3 expression induced by insulin ... We suggest that insulin induced TRB3 expression functions as an indicator how multiple insulin induced signal transduction pathways are balanced
Du et al., Mol Endocrinol 2009 : Insulin regulates TRB3 and other stress-responsive gene expression through induction of C/EBPbeta ... In this report, we have investigated the mechanism under which insulin regulates TRB3 gene expression and demonstrated that insulin induces TRB3 expression via C/EBPbeta ... We further showed that ectopic expression of C/EBPbeta augmented, whereas knockdown of C/EBPbeta reduced, TRB3 expression induced by insulin ... In addition, we presented data to show that insulin, through a similar mechanism under which insulin induces TRB3 expression, promotes the expression of genes such as ANAS, ATF3, BIP, and CHOP, which are typical stress-responsive genes
Jang et al., Korean diabetes journal 2010 : Here, we examined whether ER stress induces TRB3 expression in INS-1 cells and found that TRB3 mediates ER stress induced suppression of insulin gene expression ... The effect of TRB3 on insulin promoter was measured by transient transfection study with constructs of human insulin promoter ... A transient transfection study showed that TRB3 inhibited insulin promoter activity, suggesting that TRB3 inhibited insulin gene expression at transcriptional level