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PRKCZ — RELA

Pathways - manually collected, often from reviews:

• NCI Pathway Database Ceramide signaling pathway: PKC zeta/PAR4 complex (PRKCZ-PAWR) → NF kappa B1/RelA/I kappa B alpha complex (NFKB1-NFKBIA-RELA) (modification, inhibits)
  
• NCI Pathway Database Ceramide signaling pathway: PKC zeta/PAR4 complex (PRKCZ-PAWR) → NF kappa B1/RelA/I kappa B alpha complex (NFKB1-RELA-NFKBIA) (modification, inhibits)
  
• NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/p62/Atypical PKCs complex (TNFRSF1A-TRADD-RIPK1-TRAF2-SQSTM1-PRKCI_PRKCZ-TNF) → NF kappa B1/RelA complex (NFKB1-RELA) (modification, activates)
  Sanz et al., EMBO J 1999, Leitges et al., Mol Cell 2001
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PRKCZ — RELA (direct interaction, enzymatic study) Levy et al., Nat Immunol 2011*
• IRef Biogrid Interaction: PRKCZ — RELA (direct interaction, enzymatic study) Leitges et al., Mol Cell 2001
• IRef Biogrid Interaction: PRKCZ — RELA (physical association, affinity chromatography technology) Leitges et al., Mol Cell 2001
• IRef Hprd Interaction: RELA — PRKCZ (in vitro) Leitges et al., Mol Cell 2001, Duran et al., EMBO J 2003*
• IRef Hprd Interaction: RELA — PRKCZ (in vivo) Leitges et al., Mol Cell 2001, Duran et al., EMBO J 2003*
• IRef Intact Interaction: PRKCZ — RELA (phosphorylation reaction, experimental interaction detection) Duran et al., EMBO J 2003*
• IRef Ophid Interaction: PRKCZ — RELA (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: PRKCZ — RELA (aggregation, confirmational text mining) Leitges et al., Mol Cell 2001