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CASP12 — NOD2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Rogler et al., Curr Opin Gastroenterol 2004
:
Important new insights have been gained into the function of
caspase activating and recruitment domain-15 ( CARD15 )
/NOD2 , the first cloned susceptibility gene for Crohn disease ( CD ) ... Important new insights have been gained into the function of
caspase activating and recruitment domain-15 ( CARD15 )
/NOD2 , the first cloned susceptibility gene for Crohn disease ( CD )
Ferwerda et al., Eur J Immunol 2008
(Crohn Disease) :
Although it is known that NOD2 mediates cytokine responses to muramyl dipeptide ( MDP ), it is yet unclear whether NOD2 stimulation mediates only transcription of pro-IL-1beta mRNA, or whether
NOD2 is also
involved in the activation of
caspase-1 and release of active IL-1beta ... The synergy in IL-1beta production between NOD2 and TLR is mediated at post-translational level in a caspase-1 dependent manner, which indirectly suggests that
NOD2 also
induces caspase-1 activation
Marina-García et al., J Immunol 2008
:
Furthermore, the work provides evidence for distinct
roles of
Nod2 and Cryopyrin in the regulation of MDP induced
caspase-1 activation and IL-1beta secretion
Warren et al., J Immunol 2008
(Listeriosis) :
Multiple
Nod-like receptors
activate caspase 1 during Listeria monocytogenes infection ... We demonstrate that the presence of L. monocytogenes within the cytosolic compartment
induces caspase 1 activation through multiple
Nod-like receptors, including Ipaf and Nalp3
Hsu et al., Proc Natl Acad Sci U S A 2008
(Anthrax...) :
We found that
NOD2 through its N-terminal caspase recruitment domain directly binds and
activates caspase-1 to trigger IL-1beta processing and secretion in MDP stimulated macrophages, whereas the C-terminal leucine-rich repeats of NOD2 prevent caspase-1 activation in nonstimulated cells
Miao et al., J Clin Immunol 2010
:
This proteolysis is dependent upon
caspase 1, which is
activated by
Nod-like receptor ( NLR ) signaling
Meinzer et al., Cell Host Microbe 2012
(Yersinia pseudotuberculosis Infections) :
Concomitantly,
Nod2 interacts with and
activates caspase-1 , resulting in increased levels of IL-1ß
Saïd-Sadier et al., Biomed J 2012
(Inflammation) :
Recent research has revealed that DAMPs and PAMPs synergize to permit secretion of pro-inflammatory cytokines such as interleukin-1ß (IL-1ß) : PAMPs stimulate synthesis of pro-IL-1ß, but not its secretion ; while DAMPs can stimulate assembly of an inflammasome containing, usually, a
Nod-like receptor ( NLR ) member, and
activation of the protease
caspase-1 , which cleaves pro-IL-1ß into IL-1ß, allowing its secretion