Gene interactions and pathways from curated databases and text-mining

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LRPPRC — SOAT1

Text-mined interactions from Literome

Ernst et al., J Exp Med 2001 (Joint Diseases...) : Mitogenic hyperresponsiveness of synovial cells to the LIF/IL-6 family of cyto-kines was caused by sustained gp130 mediated SHP-2/ras/Erk activation due to impaired STAT mediated induction of suppressor of cytokine signaling (SOCS) proteins which normally limits gp130 signaling
Jenkins et al., Nat Med 2005 (Adenoma...) : Here we assess genetically the contribution of exaggerated Stat3 activation to the phenotype of gp130 ( Y757F/Y757F ) mice, in which a knock-in mutation disrupts the negative feedback mechanism on gp130 dependent Stat signaling
Lamb et al., Nucleic Acids Res 1995 : STAT protein complexes activated by interferon-gamma and gp130 signaling molecules differ in their sequence preferences and transcriptional induction properties
Kunisada et al., Circulation 1996 : Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes