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ELMO1 — RAC3
Text-mined interactions from Literome
Brugnera et al., Nat Cell Biol 2002
:
In cells, binding of Dock180 to
Rac alone is insufficient for GTP loading, and a Dock180
ELMO1 interaction is
required ... We can also detect a trimeric ELMO1 Dock180 Rac1 complex and
ELMO augments the interaction between Dock180 and
Rac
Lu et al., Methods Enzymol 2006
:
The best characterized is the
Rac activation by the
Dock180-ELMO complex
Tosello-Trampont et al., Cell Death Differ 2007
:
Although the
role of
ELMO : Dock180 in regulating
Rac activation has been well defined, the function of CED-2/CrkII in this complex is less well understood
Komander et al., Mol Biol Cell 2008
:
Significantly, although this does not affect DOCK180 GEF activity toward Rac in vivo, Rac signaling is impaired, implying additional
roles for
ELMO in mediating intracellular
Rac signaling
Fritsch et al., Cell 2013
(Fibrosis) :
In fibroblasts, GPCRs couple to PI3K through
Dock180/Elmo1 mediated
RAC activation and subsequent interaction with p110ß