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STAT3 — TRAF6
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wei et al., PloS one 2012
(Inflammation) :
The ubiquitin ligase
TRAF6 negatively
regulates the JAK-STAT signaling pathway by binding to
STAT3 and mediating its ubiquitination ... Accordingly,
TRAF6 also
down-regulated the expression of two known
STAT3 target genes, CRP and ACT
Wei et al., Acta Pharmacol Sin 2013
:
Furthermore, the treatment selectively prevented the activation of MAPKs, AKT and transcription factor AP-1 component c-Jun, but not the recruitment of
TRAF6 or the
activation of
JAK2/STAT3