Gene interactions and pathways from curated databases and text-mining

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MMP3 — SLC22A3

Text-mined interactions from Literome

Radisky et al., Nature 2005 (Cell Transformation, Neoplastic...) : Rac1b and reactive oxygen species mediate MMP-3 induced EMT and genomic instability ... We have previously investigated stromelysin-1/matrix metalloproteinase-3 (MMP-3), a stromal enzyme upregulated in many breast tumours, and found that MMP-3 can cause epithelial-mesenchymal transition (EMT) and malignant transformation in cultured cells, and genomically unstable mammary carcinomas in transgenic mice
Przybylo et al., Int J Biochem Cell Biol 2007 (Disease Progression...) : MMP-3 induced EMT involves induction of Snail, a transcription factor long studied for its role in physiological EMT but which is increasingly recognized as a factor involved in tumor progression and malignancy
Stallings-Mann et al., Cells Tissues Organs 2007 (Cell Transformation, Neoplastic) : We have identified the induction of Rac1b, an alternatively spliced variant of Rac1, as a key event in MMP induced EMT
Nelson et al., J Cell Biochem 2008 : We had shown previously that matrix metalloproteinase-3 (MMP3) can stimulate EMT of cultured mouse mammary epithelial cells through a process that involves increased expression of Rac1b, a protein that stimulates alterations in cytoskeletal structure ... We show here that cells treated with MMP-3 or induced to express Rac1b spread to cover a larger surface, and that this induction of cell spreading is a requirement of MMP-3/Rac1b induced EMT
Lee et al., Carcinogenesis 2008 (Breast Neoplasms...) : Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-beta in mammary epithelial cells via a MMP dependent mechanism
Tan et al., Am J Pathol 2010 (Fibrosis...) : AMCM induced tubular cell EMT in C1.1 cells was inhibited by broad-spectrum MMP inhibitor ( GM6001 ), MMP-2/9 inhibitor, and in AMCM after MMP-9 removal by monoclonal Ab against MMP-9 ... Furthermore, MMP-9 induced tubular cell EMT in C1.1 cells to an extent similar to transforming growth factor-beta