◀ Back to CDH1

CDH1 — MET

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CDH1 → Complex of HGF-MET (decreases) Crouch et al., Exp Cell Res 2004*
  Evidence: In epithelial carcinoma cells, c-Met activation causes the breakdown of E-cadherin cell-cell contacts leading to cell spreading. Hepatocyte growth factor (HGF), a cytokine involved in tumorigenesis and most metastases, initiates cell migration by binding to the protooncogene c-Met receptor.
• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: HGF(dimer)/MET(dimer) complex (MET) → E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1) (modification, activates)
  Brembeck et al., Genes Dev 2004
  Evidence: mutant phenotype, other species
• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: HGF(dimer)/MET(dimer) complex (MET) → E-cadherin/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1) (translocation, collaborate)
  Kimura et al., J Biol Chem 2006
  Evidence: mutant phenotype
• NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction: MET (MET) → E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1) (modification, collaborate)
  Qian et al., EMBO J 2004
  Evidence: assay
• NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction: E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1) → HGF/MET complex (HGF-MET) (modification, inhibits) Qian et al., EMBO J 2004
  Evidence: assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CDH1 — MET (physical association, affinity chromatography technology) Davies et al., Int J Mol Med 2001*
• IRef Innatedb Interaction: CDH1 — MET (unknown, -) Matteucci et al., Cell Mol Life Sci 2006*
• IRef Intact Interaction: Complex of 59 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013

Text-mined interactions from Literome

Monga et al., Cell Tissue Res 2006 : Matrigel also induced an increased association of beta-catenin with Met ( hepatocyte growth factor receptor ), whereas association with E-cadherin remained unchanged
Farazi et al., Cancer Res 2006 (Bile Duct Neoplasms...) : These murine CCAs bear histologic and genetic features of human intrahepatic CCA, including dense peritumoral fibrosis, increased inducible nitric oxide synthase, nitrotyrosine, and cyclooxygenase-2 expression, c-Met activation , cErbB2 overexpression, down-regulation of membrane associated E-cadherin , and p53 codon 248 mutation ... These murine CCAs bear histologic and genetic features of human intrahepatic CCA, including dense peritumoral fibrosis, increased inducible nitric oxide synthase, nitrotyrosine, and cyclooxygenase-2 expression, c-Met activation , cErbB2 overexpression, down-regulation of membrane associated E-cadherin , and p53 codon 248 mutation
Cossart et al., J Microsc 2008 : Moreover, they have also shown that previously unknown components discovered during the study of Listeria invasion play a role either in E-cadherin mediated cell-cell adhesion or Met signalling