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AKT1 — BDNF

Text-mined interactions from Literome

Bhave et al., J Neurosci 1999 : BDNF increased phosphorylation of Akt, a target of PI 3-kinase, and NMDA also induced Akt phosphorylation, but only after an exposure that was long enough to induce BDNF expression
Araki et al., J Neurochem 2000 : In contrast, BDNF induced activation of Akt was enhanced in neurons expressing wild-type or 4F mutant BIT/SHPS-1
Klöcker et al., J Neurosci 2000 (MAP Kinase Signaling System) : Here, we report that BDNF activates both protein kinase B (PKB) via a phosphatidyl-inositol-3'-kinase (PI-3-K) dependent mechanism and the mitogen activated protein kinases extracellular signal regulated kinase 1 ( ERK1 ) and ERK2
Mai et al., J Neurochem 2002 (Neuroblastoma) : Overexpression of GSK3beta did not affect BDNF induced phosphorylation of Akt , ERK1/2, or FKHRL1, but abolished CREB phosphorylation induced by BDNF
Zhu et al., Amino Acids 2002 : In contrast, BDNF induced Akt phosphorylation was abolished by K252a, but not by the addition of MK-801
Ruiz-León et al., J Neurochem 2004 (Neuroblastoma) : Taken together, our results suggest that simultaneous activation of at least two signalling pathways, Ras/MAPK and PI3K/Akt , is necessary to mediate a full activation of the APP promoter by BDNF
Gavaldà et al., Mol Cell Neurosci 2004 (MAP Kinase Signaling System) : In the present study, we show that the stimulation of cultured striatal cells with BDNF increased the phosphorylation of Akt and p42/p44
Leeds et al., Neurochem Int 2005 : BDNF , but not NT-3, treatment of immature CGC caused a marked, but transient activation of Akt through phosphatidylinositol (PI) 3-kinase
Li et al., Cancer Res 2005 (Neuroblastoma) : Pharmacologic inhibition of Akt, with PIA6, a phosphatidylinositol ether lipid analogue ( PIA ), blocks BDNF induced phosphorylation of Akt and the downstream target of Akt
Laurino et al., J Cell Sci 2005 : Our results show that IGF-1, but not BDNF , significantly and rapidly stimulates IRS/PI3K/Akt and membrane expansion
Sánchez-Pérez et al., Neurochem Int 2006 : Brain derived neurotrophic factor (BDNF) increases phosphorylation ( and activity ) of Akt to 350 +/- 60 % of basal and also potentiates the increase of calcium and in cGMP induced by NMDA
Soriano et al., J Neurosci 2006 (Synaptic Transmission) : Key mediators of synaptic NMDA receptor dependent neuroprotection, phosphatidylinositol 3 kinase-Akt ( PI3 kinase-Akt ) signaling to Forkhead box subgroup O ( FOXO ) export and glycogen synthase kinase 3beta ( GSK3beta ) inhibition and cAMP response element binding protein dependent ( CREB dependent ) activation of brain derived neurotrophic factor (BDNF) , can be induced only by low doses of NMDA via this action potential dependent route
Li et al., Cell Death Differ 2007 (Neuroblastoma) : Previously, we found BDNF activation of TrkB through PI3K/Akt protects NB from etoposide/cisplatin induced cell death
Perez-Pinera et al., Mol Cell Biochem 2007 (Adenocarcinoma...) : Interestingly, inhibition of neurotrophin receptor signaling using K252a prevents Akt activation in response to NGF or BDNF , induces apoptotic cell death, and diminishes the ability of A549 cells to growth in soft agar
Yang et al., J Neurobiol 2006 : In LAR-/- neurons, BDNF induced activation of TrkB, Shc, AKT , ERK, and CREB was significantly decreased ; while in LAR transfected neurons, BDNF induced CREB activation was augmented
Yoshii et al., Nat Neurosci 2007 : BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation
Zheng et al., J Biol Chem 2008 : In this study, we report that blocking clathrin, dynamin, or AP2 in cultured neurons of the central nervous system inhibited brain derived neurotrophic factor (BDNF) induced activation of Akt but not ERK ... Treating neurons with the clathrin inhibitor monodansylcadaverine or a peptide that blocks dynamin function specifically abrogated Akt pathway activation in response to BDNF but did not affect the response of other downstream effectors or the up-regulation of immediate early genes neuropeptide Y and activity regulated cytoskeleton associated protein
Zheng et al., J Neurochem 2008 (Ion Channel Gating) : The basal level of intracellular calcium gates the activation of phosphoinositide 3-kinase-Akt signaling by brain derived neurotrophic factor in cortical neurons ... We demonstrated that sub-nanomolar BDNF significantly induced Akt activation in developing cortical neurons ... Blocking NMDA receptors, L-type voltage gated calcium channels, and chelating extracellular calcium by EGTA failed to block BDNF induced Akt phosphorylation
Chaverneff et al., J Neurochem 2009 (Hypoglycemia) : BDNF increased both Akt and Erk phosphorylation, but pharmacological blockade of these kinase pathways ( with wortmannin and U0126, respectively ) did not reduce the Smad phosphorylation produced by the BMP7 + BDNF combination
Chen et al., Hippocampus 2009 : The transcription and expression of hippocampal BDNF , as well as the activation of Akt , a key survival signaling molecule, were measured following acute exercise, and also following short-term treatment with the norepinephrine reuptake inhibitor, reboxetine
Nakano et al., Life Sci 2010 : And BDNF activated Akt-1 phosphorylation by the TrkB/PI3K/Akt-1 pathway
Zhang et al., Theriogenology 2010 (MAP Kinase Signaling System) : In this study, we investigated ( using western blots ) the effects of BDNF on the phosphorylation of protein kinase B (PKB) and mitogen activated protein kinase ( MAPK ) in mouse oocytes and cumulus cells cultured in vitro
Sun et al., Tumour Biol 2010 (Multiple Myeloma) : Stimulation of MM cells with BDNF led to the activation of the phosphatidylinositol 3-kinase (PI3K)/Akt and the MEK-extracellular signal regulated protein kinase pathways
Yin et al., J Neurochem 2010 : In this study, we report RanBPM is a novel TrkB interacting protein that contributes to BDNF induced MAPK and Akt activation together with neuronal morphogenesis and survival ... Over-expression of RanBPM in PC1210 cells ( PC12 cells stably over expressing TrkB ) can significantly enhance BDNF induced MAPK and Akt activation
Yang et al., PloS one 2010 (Brain Ischemia...) : Further studies showed that EDC increased p-CREB and BDNF in the CA1 region in an ERK- and Akt dependent manner, and that cognitive outcome after GCI was preserved by EDC in an ER-dependent manner
Hwang et al., J Agric Food Chem 2011 : Hesperetin also stimulated the activation of Akt , ERK, and CREB as well as induced brain derived neurotrophic factor , PPAR? coactivator 1a ( PGC-1a ), and seladin-1 ( selective Alzheimer 's disease indicator-1 ) via both ER and TrkA in the cells
Meuchel et al., Cardiovasc Res 2011 : Both BDNF and NT3 increased phosphorylation of Akt and endothelial NO synthase (eNOS)
Li et al., Cancer 2011 (Brain Neoplasms...) : In vitro BDNF treatment induced Akt phosphorylation and rescued cells from etoposide induced cell death in cells with high TrkB expression, but not in cells with low TrkB expression ... Pretreatment of high TrkB expressing TB3 cells with perifosine blocked BDNF/TrkB induced Akt phosphorylation and inhibited BDNF 's protection of TB3 cells from etoposide treatment
Niu et al., J Neuropathol Exp Neurol 2011 : Our results indicate that BDNF increases telomerase expression and activity levels in SMNs and activates mitogen activated protein kinase/extracellular signal regulated kinases 1 and 2 and phosphatidylinositol-3-OH kinase/protein kinase B signals, and their downstream transcription factors nuclear factor-?B, c-Myc, and Sp1
Li et al., Behav Brain Res 2012 : In cultured PC-12 cells, BDNF activated PI3K/Akt signaling through the TrkB receptor, whereas stimulation of ILK/Akt occurred through TrkA/p75 ( NTR ) heteroreceptor
Fortin et al., J Neurosci 2012 : Specifically, BDNF mediated phosphorylation of threonine 308 ( T308 ) in AKT , a known substrate of CaMKK and an upstream activator of mTOR dependent translation, was prevented by ( 1 ) pharmacological inhibition of CaMKK with STO-609, ( 2 ) overexpression of a dominant negative CaMKK, or ( 3 ) short hairpin mediated knockdown of CaMKK ... Activation of CaMKK by BDNF requires transient receptor potential canonical ( TRPC ) channels as SKF-96365, but not the NMDA receptor antagonist d-APV, prevented BDNF induced GluA1 surface expression as well as phosphorylation of CaMKI, AKT ( T308 ), and mTOR ... Using siRNA we confirmed the involvement of TRPC5 and TRPC6 subunits in BDNF induced AKT ( T308 ) phosphorylation
Zurashvili et al., Mol Cell Biol 2013 : Reduced BDNF induced phosphorylation of PKB at Thr308, the PDK1 site, was observed in the mutant neurons, which was not rate limiting for the phosphorylation of those PKB substrates governing neuronal survival and apoptosis, such as FOXO1 or glycogen synthase kinase 3 ( GSK3 )
Gouarné et al., Br J Pharmacol 2013 : While BDNF activates both the PI3K/Akt and the ERK pathway, olesoxime induced only a late activation of the ERK pathways, which did not seem to play a major role in its neuroprotection against CPT. Rather, our results favour preserved mitochondrial membrane integrity by olesoxime