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AKT1 — CPA1

Text-mined interactions from Literome

Germack et al., Br J Pharmacol 2000 (MAP Kinase Signaling System) : The selective A ( 1 ) -adenosine receptor agonist N ( 6 ) -cyclopentyladenosine (CPA) stimulated time and concentration dependent increases in PKB phosphorylation in DDT ( 1 ) MF-2 cells ( EC ( 50 ) 1.3+/-0.5 nM ) ... CPA mediated increases in PKB phosphorylation were antagonized by the A ( 1 ) -adenosine receptor selective antagonist 1,3-dipropylcyclopentylxanthine ( DPCPX ) yielding an apparent K ( D ) value of 2.3 nM ... Removal of extracellular Ca ( 2+ ) and chelation of intracellular Ca ( 2+ ) with BAPTA had no significant effect on CPA induced PKB phosphorylation ... Similarly, pretreatment ( 30 min ) with inhibitors of protein kinase C ( Ro 31-8220 ; 10 microM ), tyrosine kinase ( genistein ; 100 microM ), mitogen activated protein ( MAP ) kinase kinase ( PD 98059 ; 50 microM ) and p38 MAPK ( SB 203580 ; 20 microM ) had no significant effect on CPA induced PKB phosphorylation
Germack et al., J Mol Cell Cardiol 2004 (Myocardial Ischemia...) : Adenosine ( non-selective agonist ), CPA ( A ( 1 ) selective agonist ) and Cl-IB-MECA ( A ( 3 ) selective agonist ) all increased PKB phosphorylation in a time- and concentration dependent manner
Migita et al., J Neurosci Res 2008 : CPA also induced phosphorylation of extracellular signal regulated kinase ( ERK ), mitogen activated protein kinase/ERK kinase ( MEK ), and Akt , and their phosphorylation was inhibited by DPCPA