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E2F4 — MYC
Pathways - manually collected, often from reviews:
-
FastForward regulation:
E2F4
→
MYC
(transcriptional regulation, increase)
Chen et al., Cell 2002
Evidence: REG, PROMACTIVITY, DNABINDING
-
FastForward regulation:
E2F4
→
MYC
(transcriptional regulation, unknown)
Hiebert et al., Proc Natl Acad Sci U S A 1989, Thalmeier et al., Genes Dev 1989*
Evidence: REG, PROMACTIVITY, DNABINDING
-
FastForward regulation:
E2F4
→
MYC
(transcriptional regulation, unknown)
Hiebert et al., Proc Natl Acad Sci U S A 1989
Evidence: REG, PROMACTIVITY, DNABINDING
-
FastForward regulation:
E2F1, E2F2, E2F4
→
MYC
(transcriptional regulation, increase)
Hiebert et al., Proc Natl Acad Sci U S A 1989
Evidence: DNABINDING, PROMACTIVITY, REG
-
FastForward regulation:
E2F1, E2F2, E2F4
→
MYC
(transcriptional regulation, increase)
Mudryj et al., EMBO J 1990*
Evidence: DNABINDING, PROMACTIVITY, REG
-
KEGG Cell cycle:
Complex of E2F4-E2F5-RBL1-RBL2-TFDP1-TFDP2
→
MYC
(gene expression, repression)
-
KEGG TGF-beta signaling pathway:
Complex of E2F4-E2F5-RBL1-RBL2-TFDP1
→
MYC
(gene expression, repression)
-
NCI Pathway Database E2F transcription factor network:
CEBPA/BRM/RB1/E2F4 complex (CEBPA-SMARCA2-RB1-E2F4)
→
MYC (MYC)
(transcription, inhibits)
Iakova et al., Cell 2003, Hiebert et al., Proc Natl Acad Sci U S A 1989
Evidence: mutant phenotype, reporter gene, physical interaction
Text-mined interactions from Literome
Beier et al., EMBO J 2000
:
In these cells, activation of
Myc stimulates transcription of
E2F target genes, S-phase entry and cell growth without affecting cyclin E-cdk2 kinase activity
Lang et al., J Biol Chem 2001
(Osteosarcoma) :
TRRAP and GCN5 co-expression stimulated E2F mediated transactivation, and
c-Myc repressed
E2F transactivation dependent on an intact TRRAP/GCN5 binding motif
Leone et al., Mol Cell 2001
:
Myc requires distinct
E2F activities to induce S phase and apoptosis
Chen et al., Hypertension 2006
(MAP Kinase Signaling System) :
Both ET and
c-Myc increased expression and promoter activity of
E2F , a transcription factor that has been linked to enhanced cell cycle activity
Gomis et al., Cancer Cell 2006
(Breast Neoplasms...) :
We found the transcription factor C/EBPbeta to be essential for TGFbeta induction of the cell cycle inhibitor p15INK4b by a FoxO-Smad complex and
repression of
c-MYC by an
E2F4/5-Smad complex in human epithelial cells
Hiebert et al., Proc Natl Acad Sci U S A 1989
:
We conclude that the activation of the
E2F factor, which is likely responsible for the activation of viral E2 transcription, is also
responsible for the E1A dependent induction of
MYC transcription
Oswald et al., Oncogene 1994
:
E2F dependent regulation of human
MYC : trans-activation by cyclins D1 and A overrides tumour suppressor protein functions