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IRAK1 — STAT3

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: STAT3 — IRAK1 (physical association, affinity chromatography technology) Huang et al., J Biol Chem 2004*
• IRef Hprd Interaction: IRAK1 — STAT3 (in vitro) Huang et al., J Biol Chem 2004*
• IRef Intact Interaction: Complex of 19 proteins (association, anti tag coimmunoprecipitation) Li et al., Immunity 2011
• IRef Intact Interaction: Complex of 306 proteins (association, pull down) Komarova et al., Mol Cell Proteomics 2011

Text-mined interactions from Literome

Huang et al., J Biol Chem 2004 (Arteriosclerosis) : In this report, we show that IRAK1 is mainly involved in Stat3 activation and subsequent interleukin-10 (IL-10) gene expression ... IRAK1 can directly use Stat3 as a substrate and cause Stat3 serine 727 phosphorylation
Ngo et al., Nature 2011 (Burkitt Lymphoma...) : The L265P mutant promoted cell survival by spontaneously assembling a protein complex containing IRAK1 and IRAK4, leading to IRAK4 kinase activity, IRAK1 phosphorylation, NF-?B signalling, JAK kinase activation of STAT3 , and secretion of IL-6, IL-10 and interferon-ß