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CTLA4 — IFNG

Text-mined interactions from Literome

Lee et al., J Immunol 2000 : Anti-CD154 mAb inhibited the production of IFN-gamma by 75 %, but did not inhibit IL-10 production, while CTLA4IgG4 completely inhibited the production of both IFN-gamma and IL-10
Aicher et al., J Immunol 2000 : Both ICOSL and CD152L were up-regulated on monocytes by IFN-gamma but by distinct signaling pathways
Blazevic et al., J Clin Immunol 2001 : Inhibition studies using the B7-binding fusion protein CTLA4Ig and antibodies against CD80 and CD86 demonstrate that CTLA4Ig and anti-CD86 inhibited influenza-specific T cell proliferation, interleukin (IL)-2 and interferon (IFN)-gamma production, and generation of influenza-specific CD8+ CTL
Wang et al., Scand J Immunol 2001 : Interferon (IFN)-gamma induced the upregulation of CTLA-4 expression via antigen presenting cells (APC) activation
Vasu et al., Int Immunol 2003 (Thyroiditis, Autoimmune) : Our data suggest that engagement of CTLA-4 expressed on activated autoreactive T cells in close proximity to the thyroid can increase the number of regulatory T cells and their ability to produce TGF-beta1, with a concomitant reduction in IFN-gamma and TNF-alpha, resulting in suppression of EAT
He et al., Cancer Immunol Immunother 2005 (Adenocarcinoma...) : Low level of IFN-gamma upregulates expression of PD-L1, PD-L2, CTLA-4 and Foxp3, which may partly account for the tumor immune evasion promoted by IFN-gamma
Chakrabarti et al., Vaccine 2005 : Both B7-1wa/Ig and CTLA-4/Ig , which bind to CTLA-4 and B7-1/B7-2 respectively, enhanced IFNgamma production, but not the proliferation or IL-4 release in mixed T-cell populations containing these two cell types
Chen et al., J Biol Chem 2006 : Ectopic expression of Foxp3 in non-T ( reg ) leads to repression of the interleukin 2 (IL-2) and interferon gamma (IFNgamma) genes, gain of suppressor function, and induction of genes such as CD25, GITR, and CTLA-4 , but the mode by which Foxp3 enforces this program is unclear
Ndejembi et al., J Immunol 2006 : In vitro, CTLA4Ig substantially inhibits IL-2, but not IFN-gamma production from heterogeneous memory CD4 T cells specific for influenza hemagglutinin or OVA in response to peptide challenge
Pandiyan et al., J Immunol 2007 (Inflammation) : High IFN-gamma production of individual CD8 T lymphocytes is controlled by CD152 ( CTLA-4 ) ... Indeed, production of the proinflammatory cytokine IFN-gamma , but not TNF-alpha, by CD8 T cells was inhibited by CD152 engagement
Okita et al., Oncol Rep 2007 (Neoplasms) : The secretion of IFN-gamma increased significantly in LAK/alpha-CTLA-4 ( p=0.032 )
Flores-Borja et al., Proc Natl Acad Sci U S A 2008 (Arthritis, Rheumatoid) : Furthermore, CTLA-4 blockade impaired healthy Treg suppression of T cell IFN-gamma production, but not proliferation, thereby recapitulating the unique Treg defect in RA
Zhang et al., Zhonghua Xue Ye Xue Za Zhi 2009 (Anemia, Aplastic) : ( 2 ) The expression of p-mTOR, p-S6 and IFN-gamma in refractory/relapsed AA can be suppressed by RAPA or CTLA-4Ig
Elrefaei et al., PloS one 2009 : Nevertheless, CTLA-4 blockade resulted in a significant decrease in HIV-specific TGF-beta positive and IL-10 positive CD8+ T cell responses, and a concomitant increase in HIV-specific IFN-gamma positive CD8+ T cell responses
Tan et al., J Exp Med 1993 : Accumulation of interleukin 2 (IL-2) and interferon gamma but not IL-4 mRNA was blocked by CTLA4Ig in T cells stimulated by alloantigen
Fleischer et al., Immunology 1996 : Inhibition studies using different antibodies against both molecules and the fusion protein CTLA4Ig show that only anti-CD80 and CTLA4Ig could partially inhibit antigen-specific ( tuberculin ) and polyclonal ( anti-CD3 ) lymphoproliferation and interferon-gamma (IFN-gamma) secretion of T cells cocultured with autologous monocytes
Maiuri et al., Gastroenterology 1998 (Celiac Disease) : CTLA-4Ig down-regulated the expression of CD25, intercellular adhesion molecule 1, interleukin 2, and interferon gamma ( stained lamina propria mononuclear cells/mm2 ; P < 0.05 ) induced by gliadin challenge, caused apoptosis of gliadin-specific T cells ( apoptotic T cells/mm2 ; P < 0.05 ), and inhibited the production of antiendomysial antibody ( P < 0.01 )
Gomes et al., J Infect Dis 1998 (Chronic Disease...) : CTLA-4 blockade completely restored activation induced interleukin-2 secretion and increased interferon-gamma production