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AKT1 — CBL

Pathways - manually collected, often from reviews:

• WikiPathways Insulin Signaling: GSK3B/AKT2/AKT1/SGK3/SGK1/GSK3A/PDPK1/SGK2 → STXBP2/CYTH3/KIF5B/EHD2/ARF6/RAB4A/CAP1/STXBP1/CRK/STXBP4/TBC1D4/SH2B2/EHD1/ARHGAP33/STX4/SNAP25/RHOQ/SNAP23/CBLB/STXBP3/CBL/FLOT2/CBLC/MYO1C/RHOJ/SORBS1/ARF1/RAPGEF1/VAMP2/FLOT1/KIF3A (activation)
  

Text-mined interactions from Literome

Hakak et al., Oncogene 2000 : Since activation of Akt is dependent on PI3-kinase, this suggests that the effect of Shp-2 on Akt activation may be mediated , at least in part, by its effects on the interaction between PI3-kinase and Cbl
Qin et al., Biochemistry 2003 : Under our conditions, hydrogen peroxide induced PI3K and Akt activation was independent of Lyn, Syk, Cbl , BCAP, or Ras when each was eliminated individually either by mutation or by a specific inhibitor
Li et al., Proc Natl Acad Sci U S A 2006 (Calcium Signaling) : Disruption of both CBL1 and CBL9 or CIPK23 gene in Arabidopsis reduced the AKT1 activity in the mutant roots, confirming that the Ca ( 2+ ) -CBL-CIPK pathway functions to orchestrate transporting activities in planta according to external K ( + ) availability
Guenou et al., Am J Pathol 2006 (Acrocephalosyndactylia) : Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation
Gustin et al., J Immunol 2006 : However, loss of Cbl-b does not enhance the activation of ERK or Akt , nor does it promote a greater calcium response
Tang et al., Circulation 2008 : Adenovirus mediated overexpression of a c-Cbl mutant that ablates the major tyrosine phosphorylation sites attenuated the Akt and the mammalian target of rapamycin activation and decreased the proliferation and migration of smooth muscle cells in response to PDGF-BB or fibroblast growth factor
Qu et al., FEBS Lett 2009 (Cell Transformation, Neoplastic...) : Moreover, overexpression of Cbl-b significantly suppressed ERK activation, and Cbl-b ( DN ) strongly enhanced both ERK and Akt activation
Bandi et al., Blood 2009 (Cell Transformation, Neoplastic...) : Both Cbl mutants enhanced the basal activation of Akt and prolonged the ligand dependent activation
Song et al., Cell Signal 2010 : In this study, we report that Src, c-Cbl , and PI3K are involved in the phosphorylation of Akt during TRAIL treatment
Qu et al., Mol Cell Biochem 2010 (Leukemia, Basophilic, Acute) : However, it remains unclear whether Cbl-b can regulate chemosensitivity through modulating Akt activation
Sun et al., Int J Oncol 2011 : c-Cbl , a ubiquitously expressed cytoplasmic adaptor protein, is simultaneously involved in the rapid degradation of TRAIL receptors and Akt phosphorylation during TRAIL treatment
Li et al., Mol Med Report 2011 (Lung Neoplasms) : Cbl regulated Akt and ERK signals are involved in ß-elemene induced cell apoptosis in lung cancer cells
Samoylenko et al., Carcinogenesis 2012 (Adenocarcinoma...) : Thereby, Ruk ( l ) /CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of Src, Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility
Ren et al., Plant J 2013 : The present study revealed a CBL interacting protein kinase independent regulatory mechanism of calcineurin B-like proteins in which CBL10 directly regulates AKT1 activity and affects ion homeostasis in plant cells
Qiao et al., J Immunol 2013 : Furthermore, we show that Akt-2 but not Akt-1 regulates Foxp3 expression downstream of Cbl-b
Miranti et al., Curr Biol 1998 : This pathway may regulate multiple downstream events in hematopoietic cells, including Rac induced lamellipodia formation, tyrosine phosphorylation of Cbl , and activation of JNK, ERK2 and the phosphatidylinositol 3'-kinase regulated kinase Akt