◀ Back to AKT1

AKT1 — DYNLL1

Text-mined interactions from Literome

Ibaragi et al., Mol Cancer Res 2009 (Prostatic Intraepithelial Neoplasia...) : Knocking down ANG expression by intraprostate injection of lentivirus mediated ANG-specific small interfering RNA prevents AKT induced PIN formation without affecting AKT expression and its signaling through the mammalian target of rapamycin pathway ... Neomycin, an aminoglycoside that blocks nuclear translocation of ANG, and N65828, a small-molecule enzymatic inhibitor of the ribonucleolytic activity of ANG, both prevent AKT induced PIN formation and reverse established PIN ... All three types of the ANG inhibitor suppress rRNA transcription of the prostate luminal epithelial cells and inhibit AKT induced PIN , indicating an essential role of ANG in AKT mediated cell proliferation and survival
Ibaragi et al., Clin Cancer Res 2009 (Prostatic Neoplasms) : Neamine also prevents AKT induced PIN formation as well as reverses fully developed PIN in murine prostate restricted AKT mice, accompanied by a decrease in rRNA synthesis, cell proliferation, and angiogenesis and an increase in prostate epithelial cell apoptosis
Leonard et al., Cell cycle (Georgetown, Tex.) 2013 : Inhibition of Akt activation with MK2206 reduced the whole-cell and centrosome levels of PLK-1 and ?-tubulin and also prevented the recruitment of PTEN to mitotic centrosomes