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AKT1 — IRS2

Text-mined interactions from Literome

Fasshauer et al., J Biol Chem 2000 : The phosphorylation and activity of Akt , a major downstream effector of PI 3-kinase, as well as Akt dependent phosphorylation of glycogen synthase kinase-3 and p70S6 kinase were not affected by the lack of IRS-2 ; however, there was a decrease in insulin stimulation of Akt associated with the plasma membrane
Rui et al., J Biol Chem 2001 (Carcinoma, Hepatocellular...) : Chronic insulin or IGF-1 treatment of IRS-1-deficient mouse embryo fibroblasts inhibited IRS-2 mediated activation of Akt and ERK1/2, which was reversed by lactacystin pretreatment
Jetton et al., Diabetologia 2001 : Enhanced expression of insulin receptor substrate-2 and activation of protein kinase B/Akt in regenerating pancreatic duct epithelium of 60 % -partial pancreatectomy rats ... Enhanced expression of insulin receptor substrate-2 and activation of protein kinase B/Akt in regenerating pancreatic duct epithelium of 60 % -partial pancreatectomy rats
Laviola et al., Diabetes 2001 (Diabetes Mellitus, Experimental) : In conclusion, in the diabetic heart, 1 ) IRS-1, IRS-2 , and p52 ( Shc ) are differently altered, 2 ) the levels of Akt phosphorylation on Ser-473 and Thr-308, respectively, are not coordinately regulated , and 3 ) the increased activity of proximal signaling proteins ( i.e., IRS-2 and PI 3-kinase ) is not propagated distally to GSK-3
Standaert et al., Endocrinology 2002 : Presently, in 3T3/L1 adipocytes, rosiglitazone induced sizable increases in basal glucose transport that were : dependent on PI3K, 3-phosphoinositide dependent protein kinase-1 ( PDK-1 ), and PKC-lambda ; accompanied by increases in tyrosine phosphorylation of Cbl and Cbl dependent increases in PI3K and PKC-lambda activity ; but not accompanied by increases in IRS-1/2 dependent PI3K or protein kinase B activity
Sajan et al., Mol Endocrinol 2004 : However, it is uncertain whether aPKC and PKB are activated together or differentially in response to IRS-1 and IRS-2 activation in insulin-sensitive tissues
Duan et al., J Biol Chem 2004 : Consequently, SH2-B dramatically enhanced leptin stimulated tyrosine phosphorylation of IRS1 and IRS2 in HEK293 cells stably expressing LRb, thus promoting association of IRS1 and IRS2 with the p85 regulatory subunit of PI 3-kinase and phosphorylation and activation of Akt
Kim et al., Endocrinology 2005 (Neuroblastoma) : In summary, 1 ) IRS-2 is more sensitive to IGF-I mediated degradation ; 2 ) IRS degradation is mediated by phosphatidylinositol 3-kinase and proteasome sensitive pathways ; and 3 ) high levels of IGF-IR, and possibly the subsequent increase in Akt phosphorylation, are required for efficient IRS degradation
Lingohr et al., J Biol Chem 2006 : The glucose induced rise in IRS-2 levels correlated with increased IRS-2 tyrosine phosphorylation and downstream activation of protein kinase B ... These data indicate that fluctuations of glucose in the normal physiological range ( 5-15 mM ) promote beta-cell survival via regulation of IRS-2 expression and a subsequent parallel protein kinase B activation
Fulzele et al., J Biol Chem 2007 : In DeltaIGF-1R osteoblasts, insulin signaling was markedly increased as evidenced by increased phosphorylation of insulin receptor substrate 1/2 and enhanced ERK/Akt activation
Inoue et al., J Biochem 2007 : Tyrosine phosphorylation, and thereby the activation of Stat6 and IRS-2, is critical for IL-4 signalling ; however, only the activation of Stat6, not the IRS-2 dependent phosphorylation of Akt , was perturbed in Dok-1-deficient cells stimulated with IL-4
Mardilovich et al., Cancer Res 2009 (Breast Neoplasms...) : IRS-2 is active to mediate insulin-like growth factor I-dependent signals in hypoxia, and enhanced activation of Akt in hypoxia is dependent on IRS-2 expression
Buzzi et al., Mol Cell Biol 2010 : Additionally, our signaling analyses revealed that PKBalpha , but not PKBbeta or PKBgamma, is specifically activated by overexpression of IRS2 in beta-cells and is required for IRS2 action in the islets
Park et al., J Psychopharmacol 2010 (Diabetes Mellitus, Experimental...) : Decreased IRS2 attenuated the phosphorylation of Akt and, subsequently, PDX-1 protein levels were lowered in olanzapine treated rats
Venieratos et al., Cell Signal 2010 : Inhibition of SOCS-1 expression by SOCS-1-specific small interfering RNA restored IRS-2/PI3K mediated Akt phosphorylation suppressed by high glucose
Tan et al., Cancer Res 2010 (Ovarian Neoplasms) : Intriguingly, downregulation of IRS-2 and MET contributed to the suppression of AKT signaling
Tsunekawa et al., Diabetes 2011 : In contrast, inhibition of phosphatidylinositol 3-kinase (PI3K) or PKB significantly increased IRS-2 levels in ß-cells
Giles et al., Biochem Biophys Res Commun 2013 (Melanoma...) : Additionally, we report that insulin receptor substrate-2 (IRS-2) is a target of miR-7-5p in melanoma cells, and using RNA interference ( RNAi ) we provide evidence that IRS-2 activates protein kinase B ( Akt ), and promotes melanoma cell migration