Bogush et al., J Biol Chem 2007
(Huntington Disease) :
AKT and CDK5/p35 mediate brain derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro ... We demonstrated that both the PI3K/Akt/mammalian target of rapamycin and the cdk5/p35 signal transduction pathways contribute to the induction of DARPP-32 protein levels by BDNF and that the effects are on both the transcriptional and translational levels
Pedrini et al., J Neurochem 2008
:
Furthermore, DARPP-32 induction by RA in vitro requires phosphatidylinositide 3-kinase, but is independent of tropomyosin related kinase B, cyclin dependent kinase 5, and protein kinase B Mukherjee et al., Surgery 2010
(Adenocarcinoma...) :
DARPP-32 expression in AGS cells led to increased protein levels of phospho-AKT and BCL-2