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CSF2 — TLR9
Text-mined interactions from Literome
Krutzik et al., Nat Med 2005
(Leprosy) :
CD1b+ dendritic cells were expanded by
TLR mediated upregulation of granulocyte-macrophage
colony stimulating factor ( GM-CSF ) and its receptor, promoted T cell activation and secreted proinflammatory cytokines
O'Mahony et al., International journal of medical sciences 2008
:
Of the cytokines examined, IFN-gamma and
GM-CSF caused the greatest effects on
TLR expression
Brosbøl-Ravnborg et al., Clin Exp Immunol 2009
(Crohn Disease) :
In CD patients,
TLR induced
GM-CSF secretion was impaired by both NOD2 dependent and -independent mechanisms
Fukuzono et al., Arch Biochem Biophys 2010
:
G-CSF and
GM-CSF did not
affect TLR agonist induced phosphorylation of ERK, p38, JNK, Akt, and IkappaBalpha ... These findings suggest that G-CSF and
GM-CSF exert the opposite effects on TLR agonist induced cytokine production, and G-CSF negatively
regulates TLR agonist induced cytokine production in neutrophils via activation of STAT3