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ADAR — CREB3
Text-mined interactions from Literome
Kittler et al., Neuron 2006
(Ischemic Attack, Transient) :
In this issue of Neuron, Peng et al. propose that
CREB dependent downregulation of the RNA editing enzyme
ADAR2 , resulting in defective Q/R editing of AMPA receptor GluR2 subunits and increased availability of calcium and zinc-permeable death promoting AMPA receptors, underlies the vulnerability of some neuronal populations to ischemia
Peng et al., Neuron 2006
(Disease Models, Animal...) :
Recovery of GluR2 Q/R site editing by expression of exogenous ADAR2b gene or a constitutively active
CREB , VP16-CREB, which
induces expression of endogenous
ADAR2 , protects vulnerable neurons in the rat hippocampus from forebrain ischemic insult