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CTR9 — IL1A
Text-mined interactions from Literome
Warren et al., Am J Pathol 1992
(Acute Disease...) :
Stimulation of isolated mouse alveolar macrophages with recombinant murine IL-1 beta or
IL-1 alpha resulted in rapid, dose dependent, and cell concentration dependent increases in
PAF secretion
Mizoguchi et al., J Gastroenterol Hepatol 1991
:
These results indicated that
PAF produced by hepatic sinusoidal endothelial cells is
affected by
IL-1 and arachidonic acid metabolites, suggesting that immune and inflammatory reactions in these cells may be regulated by chemical mediators produced by the cells themselves
Barthelson et al., J Allergy Clin Immunol 1990
:
The
effects of
PAF on
IL-1 release by human monocytes were studied with PAF alone and in combination with interferon-gamma ... These studies confirmed that
PAF stimulates
IL-1 release at two different ranges of PAF concentrations, 100 fM to 1 pM and 100 pM to 1 nM ...
PAF effects on
IL-1 release were specific to the form of PAF that is biologically active in most system ; ( S ) -PAF and lyso-PAF had no effect
Bussolino et al., J Lipid Mediat 1990
:
We compared the
effect of purified recombinant human TNF alpha, TNF beta and
IL-1 on the production of
platelet activating factor (PAF) in HEC
Rola-Pleszczynski et al., J Lipid Mediat 1990
:
We have recently shown that
platelet activating factor (PAF) can markedly
enhance the production of tumor necrosis factor (TNF) and
interleukin-1 (IL-1) by human monocytes stimulated with lipopolysaccharide or muramyl dipeptide ( MDP )
Pignol et al., J Lipid Mediat 1990
:
In contrast, no
effect of
PAF on
IL-1/ETAF release was observed
Pignol et al., J Lipid Mediat 1990
:
The pharmacologic modulation of the
effect of
platelet activating factor (PAF) on the
interleukin-1 (IL-1) activity present in the supernatants from lipopolysaccharide (LPS) stimulated macrophages was investigated ... Association of PT with
PAF suppressed the enhancing effect of 10 fM PAF on the
IL-1 activity present in the supernatants from LPS stimulated macrophages ... Thus, the enhancing
effect of
PAF on
IL-1 release appears to be due to the production of lipoxygenase metabolites, leading to superoxide production and alterations of cAMP levels
Barthelson et al., Cell Immunol 1990
:
The THP-1 human monocytic leukemia cell line, was used to study the mechanism by which
PAF stimulates
IL-1 release
Vlachogianni et al., Cytokine 2013
:
IL-1ß increased
lyso-PAF acetyltrasnferase activity which was peaked at 3h and kept elevated till 12h ... Finally, a transient stimulation of intracellular
PAF-AH was
induced by
IL-1ß at 3h while incubation of U-937 with the PAF acetylhydrolase inhibitor pefabloc in the presence or absence of IL-1ß led to a strong sustained increase of intracellular PAF levels
Pignol et al., Int Arch Allergy Appl Immunol 1989
:
The decrease in
IL-1 synthesis
induced by 28 micrograms
PAF and the increase in IL-2 production evoked by 1 microgram PAF were not observed in rats treated daily with the PAF antagonist, BN 52021
Bussolino et al., J Clin Invest 1986
:
To study the mechanism of
IL-1 induced
HEC-PAF production we tested the activity of 1-O-alkyl-sn-glycero-3-phosphocholine : acetyl/coenzyme A acetyltransferase in HEC ... The
regulation of
PAF generation in HEC by
IL-1 may be an important aspect of the two-way interaction between immunocompetent cells and vascular tissue
Camussi et al., J Exp Med 1988
:
TNF and
IL-1 stimulate the synthesis and release of
platelet activating factor (PAF) by neutrophils and vascular endothelial cells
Bussolino et al., J Biol Chem 1988
:
About 30 % of
PAF produced in
response to either TNF or
IL-1 is released into the medium, whereas approximately 70 % remains cell associated ... This suggests that
PAF is synthesized by the same pathway in
response to TNF or
IL-1
Breviario et al., J Immunol 1988
:
Overall these results indicate that
IL-1 induced
PAF production by EC does not significantly contribute to PMN adhesion to them
Pignol et al., Prostaglandins 1987
:
PAF-acether , at doses ranging from 1pM to 0.1 microM did not
induce a significative release and/or synthesis of
IL1 from monocytes
Bussolino et al., Pharmacol Res Commun 1986
:
Monocyte derived
interleukin 1 (IL 1) induced the
platelet activating factor (PAF) production in cultured human endothelial cells ( HEC )
Dejana et al., Blood 1987
:
PAF synthesis was
stimulated by murine and human recombinant
IL 1 alpha but not by human recombinant IL 1 beta and 22K factor
Bussolino et al., Eur J Immunol 1994
:
The generation of this elastase-like protein seems to be important for the synthesis of
PAF induced by TNF-alpha and
IL-1 alpha , as suggested by the following observations : ( a ) it precedes the synthesis of PAF ; ( b ) the inhibitors of serine protease and anti-human elastase antibody prevent the synthesis of PAF and the activation of 1-O-alkyl-2-lyso-glycerophosphocholine acetyl-CoA : acetyltransferase, which is a key enzyme of the PAF remodelling pathway ; ( c ) elastase, at concentrations similar to that detectable in the medium of cytokine activated EC, elicits a rapid synthesis of PAF by EC
Vogels et al., Infect Immun 1994
(Gram-Negative Bacterial Infections...) :
Since
IL-1 induces production of tumor necrosis factor alpha (TNF-alpha), granulocyte-macrophage colony stimulating factor ( GM-CSF ),
platelet activating factor (PAF) , and arachidonic acid metabolites, we investigated the potential role of these substances in IL-1 induced protection
Hashimoto et al., Acta Med Okayama 1993
:
These results suggest that central
IL-1 stimulates both the HPA axis and the sympathetic-adrenomedullary system, that a higher dose of IL-1 stimulates a mechanism to antagonize the elevation of blood pressure and heart rate and that central
PAF is not
involved in the control of the sympathetic-adrenomedullary system
Im et al., Cancer Res 1996
(Lung Neoplasms...) :
The effect of platelet activating factor (PAF) on experimental pulmonary metastasis by the B16F10 murine melanoma and the possible
involvement of
PAF in the activities of tumor necrosis factor alpha (TNF-alpha) and
interleukin 1alpha (IL-1alpha) in tumor metastasis were investigated
Dupuis et al., Res Immunol 1997
:
By contrast, M-CSF ( 1000 U/ml ), GM-CSF ( 100 ng/ml ),
IL1 , IL3, IL6 and stem cell factor ( 10 ng/ml ) did not
stimulate PAF production