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IL1A — NLRP3

Text-mined interactions from Literome

Aksentijevich et al., Arthritis Rheum 2002 (Inflammation...) : Consistent with the recently discovered role of CIAS1 in the regulation of interleukin-1 (IL-1) , we found evidence of increased IL-1beta, as well as tumor necrosis factor, IL-3, IL-5, and IL-6, but not transforming growth factor beta, in a mutation positive patient compared with normal controls ... IL-1 regulation by CIAS1 suggests that IL-1 receptor blockade may constitute a rational approach to the treatment of NOMID/CINCA syndrome
Toker et al., Biologics : targets & therapy 2010 : Recently the role of cryopyrin in the regulation of interleukin (IL)-1 production and activation was described and anti IL-1 therapies were found to be very effective in treating these syndromes
Yazdi et al., Proc Natl Acad Sci U S A 2010 (Pneumonia) : Unlike other particulate Nlrp3 agonists, nano-TiO ( 2 ) -dependent-Nlrp3 activity does not require cytoskeleton dependent phagocytosis and induces IL-1a/ß secretion in nonphagocytic keratinocytes
McNeela et al., PLoS Pathog 2010 (Pneumococcal Infections) : The enhancement of IL-1ß secretion by whole live S. pneumoniae and by PLY in DC required NLRP3 , identifying PLY as a novel NLRP3 inflammasome activator
Denoble et al., Proc Natl Acad Sci U S A 2011 (Osteoarthritis) : When activated, the NLRP3 ( also known as NALP3 ) inflammasome leads to the production of IL-18 and IL-1ß
Sauter et al., Cancer Biol Ther 2011 : The release of IL-1ß required the expression of ASC, caspase-1, and NLRP3 , demonstrating that doxorubicin and daunorubicin induced inflammation is mediated by the NLRP3 inflammasome
Tannahill et al., FEBS Lett 2011 : TLRs have been shown to promote glycolysis, whilst Nlrp3 mediated production of IL-1ß causes insulin resistance
Shimada et al., PloS one 2011 (Chlamydia Infections...) : In vitro investigation reveals that CP-induced IL-1ß secretion by macrophages requires TLR2/MyD88 and NLRP3/ASC/Caspase-1 signaling
Komune et al., J Virol 2011 : THP-1 cells stably expressing the V protein suppressed NLRP3 inflammasome mediated IL-1ß secretion ... These results indicate that the V protein of MV suppresses NLRP3 inflammasome mediated IL-1ß secretion by directly or indirectly interacting with NLRP3
Luheshi et al., Eur J Immunol 2012 (Peritonitis) : Here, we show that the endogenous lipid metabolite sphingosine ( Sph ) acts as a DAMP by inducing the NLRP3-inflammasome dependent secretion of IL-1ß from macrophages ... IL-1ß release induced by other well characterized NLRP3-inflammasome activators, such as ATP and uric acid crystals, in addition to NLRC4 and AIM2 inflammasome activators was also blocked by these inhibitors
Mawhinney et al., BMC neuroscience 2011 (Disease Models, Animal...) : Our previous work has shown that among the members of this family, NLRP1/NALP1 , present in neurons, plays a crucial role in inflammasome formation and the production of the inflammatory cytokines interleukin (IL) -1ß and IL-18 after various types of central nervous system injury
Coll et al., PloS one 2011 (Inflammation) : In murine bone marrow derived macrophages, CRID3 inhibited IL-1ß secretion and caspase 1 processing in response to stimulation of NLRP3 and AIM2 but not NLRC4
Hirota et al., J Allergy Clin Immunol 2012 : In this study we ( 1 ) identified NLRP3 and caspase-1 expression in human airway epithelium bronchus and primary cells, ( 2 ) characterized NLRP3 inflammasome mediated IL-1ß production from human airway epithelium in response to PM, and ( 3 ) performed in vivo PM exposure experiments with wild-type and Nlrp3 ( -/- ) mice ... Exposure of Nlrp3 ( -/- ) and wild-type mice to PM in vivo demonstrates NLRP3 dependent production of IL-1ß in the lung, airway neutrophilia, and increases in CD11c ( +hi ) /MHC class II ( +hi ) cell numbers in intrathoracic lymph nodes
Takeishi et al., Drug Discov Ther 2008 : For example, the NLR member cryopyrin/NALP3 induces cytokine secretion and lipid synthesis in response to viral dsRNA and K+ efflux, while another NLR, IPAF, induces IL-1ß ?
Koo et al., PloS one 2012 (Scrub Typhus) : Furthermore, Orientia stimulated secretion of IL-1ß and activation of caspase-1 are ASC- and caspase-1- dependent since IL-1ß production was impaired in Asc- and caspase-1-deficient macrophages but not in Nlrp3- , Nlrc4- and Aim2-deficient macrophages
Huang et al., PloS one 2012 : Our results show that AbM enhances transcription of IL-1ß and triggers NLRP3 inflammasome mediated IL-1ß secretion in human THP-1 macrophages
Hasegawa et al., J Immunol 2012 (Enterocolitis, Pseudomembranous...) : Importantly, translocated commensals were required for ASC/Nlrp3 dependent IL-1ß secretion by neutrophils
Abdalla et al., PloS one 2012 (Necrosis...) : Here we show that Mtb infection of bone marrow derived dendritic cells ( BMDCs ) induces IL-1ß secretion and that this induction is dependent upon the presence of functional ASC and NLRP3 but not NLRC4 or NOD2
Lee et al., Diabetes 2013 (Diabetes Mellitus, Type 2) : Mitochondrial reactive oxygen species and NLRP3 were required for IL-1ß synthesis in MDMs
Mulay et al., J Clin Invest 2013 (Immunologic Deficiency Syndromes...) : Calcium oxalate crystals induce renal inflammation by NLRP3 mediated IL-1ß secretion
Yazdi et al., Ann Rheum Dis 2013 (Inflammation) : Depending on the type of NLRP3 agonist, release of IL-1a is NLRP3-inflammasome/caspase-1 dependent or independent, but in both cases IL-1a processing depends on calpain protease activity
Varga et al., Immunology 2013 (Inflammation) : Intracellular ROS have been implicated in NLRP3 inflammasome mediated IL-1ß production, therefore, we aimed to study whether RWE influences the function of NLRP3 inflammasome
Pietrella et al., Eur J Immunol 2013 : Downregulation of NLRP3 by RNA interference strongly reduced the secretion of bioactive IL-1ß
Mao et al., Cell Res 2013 (Shock, Septic) : Here we show that nitric oxide ( NO ) inhibited the NLRP3 mediated ASC pyroptosome formation, caspase-1 activation and IL-1ß secretion in myeloid cells from both mice and humans
Luo et al., Clin Chem Lab Med 2013 (Cardiomyopathy, Dilated...) : In peripheral blood mononuclear cells ( PBMCs ), NLRP3 can activate interleukin-1ß (IL-1ß) , important in the chronic inflammatory process of idiopathic dilated cardiomyopathy ( IDCM )
Codolo et al., PloS one 2013 (Inflammation...) : Moreover, we observed that the secretion of IL-1ß involves NLRP3 inflammasome activation
Gomes et al., J Immunol 2013 (Brucellosis...) : In contrast, we determined that AIM2, which senses Brucella DNA, and NLRP3 are partially required for caspase-1 activation and IL-1ß secretion
Rajamäki et al., J Biol Chem 2013 (Acidosis) : The NLRP3 ( nucleotide binding domain leucine-rich repeat containing family, pyrin domain containing 3 ) inflammasome complex, assembled in response to microbial components or endogenous danger signals, triggers caspase-1 mediated maturation and secretion of IL-1ß
Lippai et al., J Leukoc Biol 2013 : Alcohol induced IL-1ß in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation
Casson et al., PLoS Pathog 2013 : Interestingly, whereas caspase-11 promotes IL-1ß release in response to the type IV secretion system through the NLRP3/ASC inflammasome, caspase-11 dependent release of IL-1a is independent of both the NAIP5/NLRC4 and NLRP3/ASC inflammasomes as well as TRIF and type I interferon signaling
Dotson et al., J Biol Chem 2013 (Tularemia) : An enhanced activation of caspase-1 and IL-1ß observed in FTL_0325 mutant infected macrophages at 24 h post-infection was independent of both AIM2 and NLRP3