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HMOX1 — MPO
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Maeshima et al., Biochem Pharmacol 2005
(Respiratory Distress Syndrome, Adult...) :
HA pretreatment markedly
induced HO-1 in pulmonary epithelial cells, and ameliorated the lung injury induced by HSR as judged by the improvement of histological changes, while it decreased TNF-alpha and inducible nitric oxide synthase gene expression, lung wet weight to dry weight ratio, and
myeloperoxidase activity
Collino et al., Dis Model Mech 2013
(Disease Models, Animal...) :
Besides, chronic
HO-1 activation
suppressed the elevated levels of
myeloperoxidase (MPO) activity, interleukin 1ß (IL-1ß) production and tumor necrosis factor-a (TNFa) production that were evoked by the ischemic injury, and increased the plasma level of the anti-inflammatory cytokine IL-10