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IL12RB1 — IL15
Text-mined interactions from Literome
Musikacharoen et al., Blood 2005
:
Promoter analyses in a mouse macrophage cell line, RAW264.7, revealed that the 2508-bp region upstream of the transcriptional start site is sufficient for the full transcriptional
activation of the
IL12RB1 gene by IFN-gamma or
IL-15 ... Consistently,
IL-15 , as a histone deacetylase inhibitor, synergistically
enhanced IL12RB1 gene expression and promoter activation by IFN-gamma through increased protein binding to ETS/PU.1 and IRE/ISRE sites
Wu et al., Eur J Immunol 1997
:
Among 16 cytokines tested, IL-2, IL-7 and
IL-15 markedly
induced IL-12Rbeta1 expression and IL-12 binding on resting PBMC, whereas IL-1alpha and tumor necrosis factor-alpha had a minimal enhancing effect