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IFNG — NOS1
Text-mined interactions from Literome
Xaus et al., J Immunol 1999
:
The stimulation of A2B receptors by adenosine or its analogues inhibits the IFN-gamma induced expression of MHC class II genes and also the
IFN-gamma induced expression of
nitric oxide synthase and of proinflammatory cytokines
Murosaki et al., Biosci Biotechnol Biochem 1999
(Escherichia coli Infections) :
NOS enhanced interleukin 12 (IL-12) and
interferon-gamma (IFN-gamma) production by normal splenocytes in the presence of the potent IL-12 inducer, heat killed Lactobacillus plantarum L-137, in vitro
Díaz-Guerra et al., J Immunol 1999
:
Negative regulation by protein tyrosine phosphatase of
IFN-gamma dependent expression of inducible
nitric oxide synthase
Saura et al., J Mol Biol 1999
:
We investigated the molecular mechanism for the synergistic
induction of inducible
nitric oxide synthase transcription by TNF-alpha and
IFN-gamma ... This interaction may explain the mechanism by which
IFN-gamma synergistically
augments inducible
nitric oxide synthase transcription
Xu et al., Biochem Pharmacol 2000
(Glioma) :
Inducible
nitric oxide synthase in P11 cells : expression in the
presence of
interferon-gamma , lipopolysaccharide, and modified serum
Yoo et al., Free Radic Biol Med 2000
:
Ionizing radiation potentiates the
induction of
nitric oxide synthase by
interferon-gamma (Ifn-gamma) or Ifn-gamma and lipopolysaccharide in bnl cl.2 murine embryonic liver cells : role of hydrogen peroxide
Tian et al., Cytokine 2000
:
Osteopontin has been shown to inhibit the
induction of inducible
nitric oxide synthase ( iNOS, or NOS2 ) by lipopolysaccharide and
interferon-gamma in the RAW264.7 mouse monocyte/macrophage line and in primary mouse proximal tubule epithelial cells
McKinney et al., Ann N Y Acad Sci 2000
:
Ionizing radiation potentiates the
induction of
nitric oxide synthase by
interferon-gamma and/or lipopolysaccharide in murine macrophage cell lines
Maggi et al., EMBO J 2000
:
Furthermore, dsRNA +
IFN-gamma stimulate inducible
nitric oxide synthase expression, IkappaB degradation and NF-kappaB nuclear localization to similar levels in macrophages isolated from PKR ( -/- ) and PKR ( +/+ ) mice
Yamaoka et al., Arch Dermatol Res 2000
:
Ultraviolet B radiation downregulates inducible
nitric oxide synthase expression
induced by
interferon-gamma or tumor necrosis factor-alpha in murine keratinocyte Pam 212 cells
Chiarugi et al., J Leukoc Biol 2000
:
IFN-gamma induced indoleamine 2,3-dioxygenase (IDO) and
NO synthase (NOS) and increased the synthesis of 3OH-kynurenine, QUIN, and NO that accumulated in the incubation medium where they reached neurotoxic levels
Momose et al., Biochim Biophys Acta 2000
:
Phorbol ester synergistically increases interferon regulatory factor-1 and inducible
nitric oxide synthase induction in
interferon-gamma treated RAW 264.7 cells
Kang et al., Neurosci Lett 2001
(Encephalitis...) :
Identification of protein kinase C isoforms involved in
interferon-gamma induced expression of inducible
nitric oxide synthase in murine BV2 microglia
Español et al., Int Immunopharmacol 2001
:
We confirm
NOS activation because
IFN gamma stimulates nitrite production and enzyme activity in SMG
Paludan et al., Eur Cytokine Netw 2001
:
Interferon (IFN)-gamma and Herpes simplex virus/tumor necrosis factor-alpha synergistically
induce nitric oxide synthase 2 in macrophages through cooperative action of nuclear factor-kappa B and IFN regulatory factor-1
Sekine et al., Endocrinology 2001
:
This action of GH may be sufficient to suppress the synergistic
induction of inducible
nitric oxide synthase by
interferon-gamma and TNFalpha, thereby preventing the cytotoxicity to beta-cells
Cochrane et al., J Interferon Cytokine Res 2001
:
In contrast, inhibitors of PKA or
NOS , but not catalase,
prevented FSK induced suppression of
IFN-gamma production
Murakami et al., Carcinogenesis 2002
(Adenocarcinoma...) :
The combined lipopolysaccharide- and
interferon-gamma stimulated protein expressions of inducible
nitric oxide synthase and cyclooxygenase (COX)-2, together with the release of tumor necrosis factor-alpha, in RAW 264.7 mouse macrophages were also markedly diminished
Fecker et al., J Invest Dermatol 2002
(Breast Neoplasms...) :
Inducible
nitric oxide synthase is expressed in normal human melanocytes but not in melanoma cells in
response to tumor necrosis factor-alpha,
interferon-gamma , and lipopolysaccharide
Raso et al., Br J Pharmacol 2002
:
Leptin potentiates
IFN-gamma induced expression of
nitric oxide synthase and cyclo-oxygenase-2 in murine macrophage J774A.1
Levesque et al., Leukemia 2003
(Leukemia, Lymphocytic, Chronic, B-Cell...) :
IL-4 and
interferon gamma regulate expression of inducible
nitric oxide synthase in chronic lymphocytic leukemia cells
Hsiao et al., Biochem Pharmacol 2003
(Shock, Septic) :
A novel antioxidant, octyl caffeate, suppression of
LPS/IFN-gamma induced inducible
nitric oxide synthase gene expression in rat aortic smooth muscle cells
Wei et al., Biochem Pharmacol 2003
:
Upon stimulation with 1 microg/mL lipopolysaccharide plus 100 U/mL
interferon-gamma which
induced the expression of inducible
nitric oxide synthase , cultured astrocytes generated large amounts of NO as measured by nitrite assay and ESR technique
Chen et al., J Immunol 2003
:
Inhibition of
IFN-gamma mediated inducible
nitric oxide synthase induction by the peroxisome proliferator activated receptor gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathway
Lüder et al., Int J Parasitol 2003
(Toxoplasmosis, Animal) :
Inducible
nitric oxide synthase transcripts
induced by
interferon-gamma alone or in combination with lipopolysaccharide were also dose-dependently down-regulated after infection of RAW264.7 cells with T. gondii
Cunha et al., Biochem Biophys Res Commun 1992
:
Interleukin-10 (IL-10) inhibits the
induction of
nitric oxide synthase by
interferon-gamma in murine macrophages
Kilbourn et al., J Natl Cancer Inst 1992
(Hypotension) :
Induction of
nitric oxide synthase is
augmented by
interferon-gamma and blocked by IL-1 receptor antagonist and by inhibitors of RNA or protein synthesis
Gendron et al., J Neurochem 2003
:
P2X7 nucleotide receptor activation enhances
IFN gamma induced type II
nitric oxide synthase activity in BV-2 microglial cells
van der Veen et al., J Neuroimmunol 2003
(Encephalomyelitis, Autoimmune, Experimental...) :
Tissue expression of inducible
nitric oxide synthase requires
IFN-gamma production by infiltrating splenic T cells : more evidence for immunosuppression by nitric oxide
Huang et al., FEBS Lett 2003
:
Our previous study has shown that lipophilic 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors of statins can inhibit
interferon-gamma induced inducible
nitric oxide synthase gene expression in RAW264.7 macrophages
Vega et al., J Leukoc Biol 2004
:
This report focuses on the modulatory role of endogenous H ( 2 ) O ( 2 ) on lipopolysaccharide
(LPS)/interferon-gamma (IFN-gamma) induced inducible
nitric oxide synthase ( NOS2 ) gene expression in rat peritoneal macrophages
Hwang et al., Biochem Biophys Res Commun 2004
:
LY294002 inhibits
interferon-gamma stimulated inducible
nitric oxide synthase expression in BV2 microglial cells
Palomba et al., J Biol Chem 2004
:
Previous results have indicated that lipopolysaccharide (LPS) plus
interferon-gamma (IFNgamma) inhibits
nitric-oxide synthase (NOS)-I activity in glial cells
Pannu et al., J Neurosci 2004
(Demyelinating Diseases...) :
A novel role of lactosylceramide in the regulation of
lipopolysaccharide/interferon-gamma mediated inducible
nitric oxide synthase gene expression : implications for neuroinflammatory diseases
Huang et al., Mol Pharmacol 2004
:
p38 Mitogen activated protein kinase mediates synergistic
induction of inducible
nitric-oxide synthase by lipopolysaccharide and
interferon-gamma through signal transducer and activator of transcription 1 Ser727 phosphorylation in murine aortic endothelial cells
Coffey et al., Exp Lung Res 2004
(Sepsis...) :
Induction of inducible
nitric oxide synthase by
lipopolysaccharide/interferon gamma and sepsis down-regulates 5-lipoxygenase metabolism in murine alveolar macrophages
Koh et al., J Clin Invest 2004
(Arteriosclerosis) :
Neutralizing
IFN-gamma completely
prevented both vascular dysfunction and changes in
NOS expression ; neutralizing TNF reduced IFN-gamma production and partially prevented dysfunction
Kim et al., Biochem Biophys Res Commun 2005
:
Protein expression of inducible
nitric oxide synthase and cyclooxygenase-2, and production of NO by these cells were
induced by LPS or
IFN-gamma
Shen et al., Neurochem Int 2005
(Encephalitis...) :
Distinct signaling pathways for
induction of type II
NOS by
IFNgamma and LPS in BV-2 microglial cells
Hamby et al., J Neurosci Methods 2006
:
Purified monolayers appeared morphologically normal 24h after LME treatment and expressed
nitric oxide synthase-2 (NOS-2) and cyclooxygenase-2 (COX-2) proteins upon
stimulation with LPS plus
IFNgamma , albeit to a lower level than unpurified monolayers
Martey et al., Biochem Pharmacol 2005
:
In keratinocytes,
IFN-gamma stimulates expression of inducible
nitric oxide synthase ( NOS2 )
Vila-del Sol et al., J Leukoc Biol 2007
:
Requirement of tumor necrosis factor alpha and nuclear factor-kappaB in the
induction by
IFN-gamma of inducible
nitric oxide synthase in macrophages
Liby et al., Cancer Res 2007
(Adenocarcinoma...) :
The mechanisms of action of CDDO-ME and CDDO-EA that are germane to these in vivo findings are the following results shown here in cell culture : ( a ) suppression of the ability of
IFN-gamma to
induce de novo formation of
nitric oxide synthase in a macrophage-like cell line RAW264.7, ( b ) induction of heme oxygenase-1 in these RAW cells, and ( c ) suppression of phosphorylation of the transcription factor signal transducers and activators of transcription 3 as well as induction of apoptosis in human lung cancer cell lines
Skorokhod et al., Malaria journal 2007
(Malaria) :
Malarial pigment haemozoin,
IFN-gamma , TNF-alpha, IL-1beta and LPS do not
stimulate expression of inducible
nitric oxide synthase and production of nitric oxide in immuno purified human monocytes
Pfaff et al., Int J Parasitol 2008
(Parasitemia...) :
Impact of foetus and mother on
IFN-gamma induced indoleamine 2,3-dioxygenase and inducible
nitric oxide synthase expression in murine placenta following Toxoplasma gondii infection ... The tryptophan catabolising enzyme indoleamine 2,3-dioxygenase (IDO), as well as inducible
nitric oxide synthase ( NOS2 ) are
induced by
IFN-gamma and can play extremely diverse roles in immune regulation, defence against pathogens and physiological homeostasis
Kim et al., J Biol Chem 2008
(Glioma) :
C6 glioma cell insoluble matrix components enhance
interferon-gamma stimulated inducible
nitric-oxide synthase/nitric oxide production in BV2 microglial cells
Choi et al., J Leukoc Biol 2008
:
NOS was markedly
inhibited by blocking antibodies to
IFN-gamma and TNF-alpha, suggesting the key role of these lymphocyte cytokines in mediating NOS
Ward et al., Bioinorganic chemistry and applications 2003
:
However inducible nitric oxide synthase activity was significantly reduced in these macrophages as shown by decreases in LPSinduced and
LPS+IFNgamma induced
NOS activation
Xu et al., Stem Cells 2009
:
C/EBPbeta knockdown also inhibited the synergistic expression of CXCL1, inducible
nitric oxide synthase , and CCL5 in
response to concomitant
IFNgamma and TNFalpha
Bombeiro et al., Neuroimmunomodulation 2010
(Chagas Disease...) :
We suggest that overproduction of NO may account for neuronal death at the spinal cord of T. cruzi infected IL-12p40KO mice and that
IFN-gamma and S100beta may
contribute to
NOS activation in the absence of IL-12
Yoshioka et al., Mol Reprod Dev 2012
:
TNF and
IFNG stimulated
NOS activity ( P? < ?0.05 ) and 1400W, a specific inhibitor of iNOS, reduced NO production stimulated by TNF and IFNG in LECs ( P? < ?0.05 )
Sato et al., Mech Ageing Dev 1995
:
Nitric oxide synthase (NOS) activity was
enhanced in human umbilical vein endothelial cells ( HUVECs ) by the combined stimulation with
IFN-gamma plus IL-1beta, TNF-alpha and LPS which was accompanied by cell death
Yamada et al., Biochem Biophys Res Commun 1993
:
Nitric oxide and
nitric oxide synthase mRNA
induction in mouse islet cells by
interferon-gamma plus tumor necrosis factor-alpha
Koide et al., Hypertension 1994
:
These findings suggest that
interferon gamma directly
induces the expression of the inducible
nitric oxide synthase gene, whereas tumor necrosis factor-alpha and interleukin-1 beta induce it, at least in part, via the induction of intermediary protein ( s ), and that transforming growth factor-beta 1 inhibits cytokine induced nitric oxide production by blocking the posttranscriptional synthesis of inducible nitric oxide synthase
Nussler et al., J Biol Chem 1994
:
The present study demonstrates that lipopolysaccharide and
interferon-gamma , which
induce NOS in the murine macrophage cell line RAW 264.7, also coinduce activity and mRNA for argininosuccinate synthetase, which is limiting for arginine synthesis
Melillo et al., J Biol Chem 1994
:
The ability of picolinic acid to augment
IFN-gamma dependent
NOS mRNA expression was associated with a parallel increase in transcription, as demonstrated by nuclear run-on experiments
Lin et al., Infect Immun 1994
:
Quantification by Northern ( RNA ) blot analyses demonstrated that
IFN-gamma in combination with TNF-alpha or LPS
increased markedly the accumulation of
mac-NOS and TNF-alpha mRNAs in a time dependent manner with a concomitant increase in NO and TNF-alpha production
Yan et al., J Immunol 1994
:
In addition,
NOS activity was not
induced in PMNs by LPS, IL-1 beta, or
IFN-gamma
Florquin et al., J Exp Med 1994
(Shock, Septic) :
In vitro experiments indicated that
NO synthase (NOS) inhibition by N-nitro-L-arginine methyl ester ( L-NAME )
enhanced IFN-gamma and TNF production by splenocytes in response to SEB
Murata et al., Int J Cancer 1994
(Colonic Neoplasms) :
NOS activity was
increased by TNF-alpha and
IFN-gamma , and significantly reduced by tumor-cell conditioned medium
Paul et al., Br J Pharmacol 1995
:
5. LPS- and
IFN gamma induced
NOS activity was reduced by the tyrosine kinase inhibitor genestein ... 6. Nicotinamide, an inhibitor of poly-ADP ribosylation, abolished LPS- and
IFN gamma induced
NOS activity ... 7. Brefeldin A, an inhibitor of a factor which stimulates nucleotide exchange activity on the 21 kDa ADP-ribosylation factor, ARF, reduced LPS- and
IFN gamma induced
NOS activity by approximately 80 % ... 8. These results suggest the involvement of protein kinase C, tyrosine kinase and poly-ADP ribosylation pathways in the
regulation of the induction of
nitric oxide synthase in RAW 264.7 macrophages by LPS and
IFN gamma
Park et al., J Neurosci Res 1994
(Glioma) :
The NOS activity induced by LPS in C6 cells was maximal at 4 to 8 hr and then rapidly decreased, while
NOS activity
induced by IL-1
beta/IFN-gamma slowly decreased after 4 hr
Hattori et al., Nihon Naibunpi Gakkai Zasshi 1995
:
[ The synergistic
effect of
interferon-gamma on the induction of
nitric oxide synthase by lipopolysaccharide in vascular smooth muscle ]
Hamilton et al., J Clin Invest 1995
:
The cooperative
effects of
IFN gamma and LPS on the expression of the inducible
nitric oxide synthase gene were suppressed by oxidized LDL while the antagonistic effect of IFN gamma on LPS induced expression of the TNF receptor type II mRNA was not altered
Renier et al., Arterioscler Thromb Vasc Biol 1995
:
The ability of LPL to augment
IFN-gamma dependent
NOS mRNA expression was associated with an increase in the NOS gene transcriptional activity but not in the NOS mRNA stability
Ringheim et al., Biochem Biophys Res Commun 1995
:
Stimulation of these cells with E. coli lipopolysaccharide and
interferon-gamma resulted in a significant induction of
nitric oxide synthase activity with approximately 20 % of the total activity localized to the cell membrane
Unno et al., Crit Care Med 1995
:
When intestinal epithelial ( Caco-2BBe ) monolayers were incubated with
interferon-gamma in the
presence of inhibitors of
nitric oxide synthase ( NG-monomethyl-L-arginine NG-nitro-L-arginine-methyl ester, or NG-nitro-L-arginine ), both of the effects of the cytokine ( i.e., increased epithelial permeability and increased production of nitrite/nitrate ) were attenuated
Maciejewski et al., J Clin Invest 1995
:
IFN-gamma and TNF-alpha, potent inhibitors of hematopoiesis,
induce nitric oxide synthase (NOS) in various cell types
Nishiya et al., FEBS Lett 1995
(Glioma) :
Herbimycin A, a potent tyrosine kinase inhibitor, suppressed
nitric oxide synthase (NOS) induced by lipopolysaccharide (LPS) and
interferon-gamma (IFN-gamma) in C6 glial cells
Misko et al., J Neuroimmunol 1995
(Encephalomyelitis, Autoimmune, Experimental...) :
Mediation of inflammation by encephalitogenic cells :
interferon gamma induction of
nitric oxide synthase and cyclooxygenase 2
Assreuy et al., Br J Pharmacol 1993
:
1. A murine macrophage cell line, J774, expressed
nitric oxide ( NO ) synthase activity in
response to
interferon-gamma ( IFN-gamma, 10 u ml-1 ) plus lipopolysaccharide ( LPS, 10 ng ml-1 )
Adamson et al., Toxicol Appl Pharmacol 1993
:
In combination, TNF alpha and
IFN-gamma markedly
increased NOS activity beyond that expected for a merely additive effect
Goureau et al., Proc Natl Acad Sci U S A 1993
:
Transforming growth factor beta 1 slightly increases the production of nitrite, an oxidation product of NO, induced by LPS plus IFN-gamma, whereas acidic and basic FGFs markedly inhibit the nitrite release due to LPS/IFN-gamma in a concentration dependent manner, and epidermal growth factor did not modify
LPS/IFN-gamma induced
NOS activity ... Results with heparin, suramin, and tyrphostin suggest involvement of the high-affinity receptor for FGF in its inhibition of
LPS/IFN-gamma stimulated
NOS activity
Bogdan et al., J Immunol 1993
:
Traces of bacterial lipopolysaccharide suppress
IFN-gamma induced
nitric oxide synthase gene expression in primary mouse macrophages
Becker et al., In Vivo 1993
(Neoplasms...) :
It was also reported ( 4 ) that
Interferon gamma (IFN-gamma) , produced by murine T helper 1 cells,
induces NOS activity in macrophages, while T helper 2 cells which produce Interleukin-4 (IL-4) inhibit the expression of NOS in macrophages
Lee et al., J Neuroimmunol 1993
:
Induction of
nitric oxide synthase activity in human astrocytes by interleukin-1 beta and
interferon-gamma
Karupiah et al., Science 1993
(Ectromelia, Infectious) :
Inhibition of viral replication by
interferon-gamma induced
nitric oxide synthase
Vilcek et al., Int Arch Allergy Immunol 1994
(Bacterial Infections) :
Other studies have shown that the transcription factor IRF-1 is essential for the
IFN-gamma mediated activation of the gene for the inducible
nitric oxide synthase
Deguchi et al., J Interferon Cytokine Res 1995
:
Exogenous and endogenous type I interferons inhibit
interferon-gamma induced nitric oxide production and
nitric oxide synthase expression in murine peritoneal macrophages
Sternberg et al., Eur J Immunol 1996
(Trypanosomiasis, African) :
Nitric oxide mediated suppression of T cell responses during Trypanosoma brucei infection : soluble trypanosome products and
interferon-gamma are synergistic
inducers of
nitric oxide synthase
Hussaini et al., J Leukoc Biol 1996
:
IFN-gamma also markedly
increased expression of inducible
nitric oxide synthase (NOS) , as expected ; however, the increase in nitric oxide was not responsible for the down-regulation of LRP expression since the NOS inhibitor, N ( G ) -monomethyl-L-arginine, did not preserve LRP expression in IFN-gamma treated cells
Duval et al., Mol Pharmacol 1996
:
Induction of hepatic
nitric oxide synthase (NOS) by tumor necrosis factor-alpha (TNF alpha), interleukin-1 beta (IL-1 beta),
interferon-gamma (IFN gamma) , interleukin-6 (IL-6), and lipopolysaccharide was assessed as activity and immunoreactive protein ...
NOS induction by TNF alpha was dose dependent from concentrations of 0.06 to 60 nM and was
increased 2-3-fold by
IFN gamma
Sanchez-Bueno et al., Biochem Biophys Res Commun 1996
(Fibrosarcoma) :
Interferon-gamma dependent expression of inducible
nitric oxide synthase , interleukin-12, and interferon-gamma inducing factor in macrophages elicited by allografted tumor cells
Coffey et al., Biochem Pharmacol 1996
:
Inhibition was greatest if THC was added 1-4 hr before
induction of
nitric oxide synthase (NOS) by LPS and
IFN-gamma , and declined with time after addition of the inducing agents
Komatsu et al., J Neuroimmunol 1996
(Astrocytoma...) :
Interferon-gamma induced type I
nitric oxide synthase activity inhibits viral replication in neurons ... Thus,
IFN-gamma induced type I
NOS activity may play an important role in host immunity against neurotropic viral infections
Eason et al., Arch Int Pharmacodyn Ther 1995
:
Involvement of tyrosine kinase and protein kinase C in the
induction of
nitric oxide synthase by lipopolysaccharide and
interferon-gamma in J774 macrophages ... These results provide strong evidence for the involvement of tyrosine kinases in the
induction of
nitric oxide synthase by LPS and
IFN-gamma in J774 macrophages
Lu et al., J Immunol 1996
:
Induction of
nitric oxide synthase in mouse dendritic cells by
IFN-gamma , endotoxin, and interaction with allogeneic T cells : nitric oxide production is associated with dendritic cell apoptosis ... Thus, although DC function initially as the most potent APCs for T cell activation, DC
induced to synthesize
NOS by
IFN-gamma may inhibit ( allogeneic ) T cell proliferation : NO may suppress lymphocyte proliferation and also induce apoptosis of the most potent source of alloantigenic stimulation
Vogl et al., Liver 1996
(Liver Cirrhosis, Experimental) :
Interferon-gamma (IFN-gamma) induced the
nitric oxide synthase more rapidly in macrophage cultures from cirrhotic livers than in controls
Ding et al., Mol Psychiatry 1997
:
Cultures of human fetal astrocytes and microglia produce inducible
nitric oxide synthase and nitric oxide in
response to
Interferon gamma and Interleukin 1 beta
Sekkaï et al., Arch Biochem Biophys 1997
:
Indoleamine 2,3-dioxygenase (IDO) and
nitric oxide synthase (NOS) type II are
induced in macrophages by
interferon (IFN)-gamma and lipopolysaccharide (LPS)
Stewart et al., J Neurochem 1997
:
Pretreatment of astrocytes with interferon-alpha/beta impairs
interferon-gamma induction of
nitric oxide synthase ... Furthermore, pretreatment of astrocytes with interferon-alpha/beta inhibited ( approximately 65 % )
stimulation by
interferon-gamma of
nitric oxide synthase activity and nitric oxide release
Nishiya et al., FEBS Lett 1997
(Glioma) :
Activation of Stat1 and subsequent transcription of inducible
nitric oxide synthase gene in C6 glioma cells is
independent of
interferon-gamma induced MAPK activation that is mediated by p21ras
Taylor et al., Cancer Res 1997
:
Bryostatin-1 and
IFN-gamma synergize for the expression of the inducible
nitric oxide synthase gene and for nitric oxide production in murine macrophages
Gansauge et al., FEBS Lett 1997
:
Induction of inducible
nitric oxide synthase by tumor necrosis factor-alpha,
interferon-gamma and interleukin-1beta inhibited cell proliferation and led to a G1 arrest
Guo et al., J Clin Invest 1997
:
Interferon gamma and interleukin 4
stimulate prolonged expression of inducible
nitric oxide synthase in human airway epithelium through synthesis of soluble mediators
von Knethen et al., FASEB J 1997
:
Lipopolysaccharide/interferon gamma up-regulated inducible
nitric oxide synthase and caused nitric oxide generation and concomitant apoptotic cell death in RAW 264.7 macrophages
Jungi et al., Clin Exp Immunol 1997
:
Antagonistic
effects of IL-4 and
interferon-gamma (IFN-gamma) on inducible
nitric oxide synthase expression in bovine macrophages exposed to gram positive bacteria
McKinney et al., J Leukoc Biol 1998
:
Ionizing radiation potentiates the
induction of
nitric oxide synthase by
IFN-gamma and/or LPS in murine macrophage cell lines : role of TNF-alpha
Kleinert et al., Br J Pharmacol 1998
:
1. In human epithelial-like DLD-I cells,
nitric oxide synthase (NOS) II expression was
induced by
interferon-gamma ( 100 u ml(-1) ) alone and, to a larger extent, by a cytokine mixture ( CM ) consisting of interferon-gamma, interleukin-1beta ( 50 u ml(-1) ) and tumor necrosis factor-alpha ( 10 ng ml(-1) )
Koblish et al., J Exp Med 1998
:
Immune suppression by recombinant interleukin ( rIL ) -12 involves
interferon gamma induction of
nitric oxide synthase 2 ( iNOS ) activity : inhibitors of NO generation reveal the extent of rIL-12 vaccine adjuvant effect
Hoffmann et al., Eur J Pharmacol 1998
:
We show that G-CSF suppresses
interferon-gamma/tumor necrosis factor-alpha (TNF-alpha)
induced inducible
nitric oxide synthase gene expression detected as inducible nitric oxide synthase cDNA ( cDNA concentration was 633 +/- 38 amol/microg total RNA following 24 h incubation with 100 U/ml interferon-gamma/500 U/ml TNF-alpha, and 440 +/- 14 amol/microg total RNA following 24 h incubation with 250 U/ml G-CSF +/- 100 U/ml interferon-gamma/500 U/ml TNF-alpha, respectively )
Frank et al., J Invest Dermatol 1998
:
Coordinated induction of inducible
nitric oxide synthase and GTP-cyclohydrolase I is
dependent on inflammatory cytokines and
interferon-gamma in HaCaT keratinocytes : implications for the model of cutaneous wound repair
Ookawauchi et al., J Hepatol 1998
:
The
effect of tumor necrosis factor-alpha and
interferon-gamma on L-arginine transport, mRNA expression of cationic amino acid transporter and inducible
nitric oxide synthase , and nitric oxide production of stellate cells was assessed ...
Interferon-gamma in combination with tumor necrosis factor-alpha
induced nitric oxide production with an enhancement in cationic amino acid transporter-2B mRNA expression, inducible
nitric oxide synthase mRNA expression, and L-arginine transport, while extracellular L-lysine competitively inhibited this nitric oxide production ... In transformed hepatic stellate cells, tumor necrosis factor-alpha and
interferon-gamma have a crucial role in nitric oxide production, and extracellular L-arginine transport and inducible
nitric oxide synthase expression are
regulated in a differential cytokine-specific manner