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MYLIP — ZEB2

Text-mined interactions from Literome

Christoffersen et al., RNA 2007 : miR-200b mediates post-transcriptional repression of ZFHX1B ... We show that Zfhx1b and miR-200b are regionally coexpressed in the adult mouse brain and that miR-200b represses the expression of Zfhx1b via multiple sequence elements present in the 3'-untranslated region ... Overexpression of miR-200b leads to repression of endogenous ZFHX1B , and inhibition of miR-200b relieves the repression of ZFHX1B
Nakada et al., J Pathol 2008 (Carcinoma, Renal Cell...) : Furthermore, we found that overexpression of miR-141 and miR-200c caused down-regulation of ZFHX1B and up-regulation of E-cadherin in two renal carcinoma cell lines, ACHN and 786-O
Adam et al., Clin Cancer Res 2009 (Carcinoma...) : Stable expression of miR-200 in mesenchymal UMUC3 cells increased E-cadherin levels, decreased expression of ZEB1, ZEB2 , ERRFI-1, and cell migration, and increased sensitivity to EGFR blocking agents
Chen et al., Mol Cell Biol 2010 (Neoplasms) : These observations suggest a strategy for inhibiting angiogenesis by either recapitulating miR-221 expression or inhibiting ZEB2 activation
Wang et al., Toxicological sciences : an official journal of the Society of Toxicology 2011 (Cell Transformation, Neoplastic) : Further mechanistic studies showed that depletion of miR-200 in arsenite transformed cells involved induction of the EMT inducing transcription factors zinc-finger E-box binding homeobox factor 1 ( ZEB1 ) and ZEB2 and increased methylation of miR-200 promoters
Putta et al., J Am Soc Nephrol 2012 (Albuminuria...) : In the kidneys of diabetic mice, inhibition of miR-192 significantly increased Zeb1/2 and decreased gene expression of collagen, TGF-ß, and fibronectin ; immunostaining confirmed the downregulation of these mediators of renal fibrosis
Kurashige et al., Ann Surg Oncol 2012 (Carcinoma...) : miR-200b regulates ZEB2 expression and thus controls metastasis in gastric cancer
Wang et al., Proc Natl Acad Sci U S A 2013 : Mechanistic studies showed that miR-200s significantly repress the expression of zinc finger E-box binding homeobox 2 ( ZEB2 ) through directly targeting its 3 ' UTR and direct inhibition of ZEB2 can mimic the effects of miR-200s on iPSC generation and MET process
Deshpande et al., Diabetes 2013 (Diabetic Nephropathies) : In vitro promoter regulation studies show that TGF-ß induces reciprocal activation of miR-192 and p53, via the miR-192 target Zeb2 , leading to augmentation of downstream events related to DN. Inverse correlation between miR-192 and Zeb2 was observed in glomeruli of human subjects with early DN, consistent with the mechanism seen in mice
Renthal et al., Nat Rev Endocrinol 2013 : This article reviews the actions of the miR-200 family and their P4-regulated targets-the transcription factors ZEB1, ZEB2 and STAT5B-in the pregnant myometrium, as well as the role of miR-199a-3p and miR-214 and their mutual target PTGS2