◀ Back to NA

NA — PTGS2

Text-mined interactions from Literome

Origuchi et al., J Lab Clin Med 2000 : We examined whether the antioxidant N-acetylcysteine (NAC) inhibited COX-2 expression induced in the human osteoblastic cell line MG63 by interleukin-1beta (IL-1beta) ... According to Western blot and reverse transcription-polymerase chain reaction ( RT-PCR ) test results, NAC inhibited IL-1beta induced COX-2 expression in protein and messenger RNA ... These results suggested that NAC inhibited both COX-2 expression and NFkappaB nuclear translocation in MG63, which in turn indicated that NAC could inhibit the inflammatory process involved in bone resorption by regulating COX-2 expression at the level of transcription
Huang et al., J Biomed Mater Res B Appl Biomater 2005 : Protective effect of NAC on formaldehyde-containing-ZOE based root-canal-sealers induced cyclooxygenase-2 expression and cytotoxicity in human osteoblastic cells
Chung et al., Toxicological sciences : an official journal of the Society of Toxicology 2007 : Upregulation of NF-kappaB and COX-2 expression by AcQ treatment was suppressed by the antioxidant N-acetylcysteine (NAC)
Temma-Asano et al., Gynecol Obstet Invest 2011 (Obstetric Labor, Premature) : We also examined the effect of N-acetylcysteine (NAC) on 4-HNE induced COX-2 expression ... NAC inhibited 4-HNE induced COX-2 expression
Chen et al., Chem Res Toxicol 2012 (MAP Kinase Signaling System...) : This 2-ABP induced COX-2 expression was attenuated by ROS scavenger NAC and NADPH oxidase inhibitors apocynin and DPI