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IL6 — MAP2K6
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Gobert et al., J Biol Chem 2004
:
In contrast, inhibitors of protein kinase A or C,
mitogen activated protein kinase kinase , and phosphoinositide 3-kinase
had no effect on
IL-6 mRNA levels
Yang et al., Microvasc Res 2009
(AIDS Dementia Complex) :
Inhibitors of STAT1,
mitogen activated protein kinase kinase ( MEK ) ( PD98059 ), and phosphatidyl inositol 3 kinase (PI3K) ( LY294002 ), blocked gp120 induced STAT1 activation and significantly
diminished IL-8-,
IL-6- , and gp120 induced monocyte adhesion and migration across in vitro BBB models
Kulas et al., J Biol Chem 1996
:
While expression of CD45 was associated with a decrease in the responsiveness of early insulin receptor signaling,
interleukin 6-dependent activation of
mitogen activated protein kinase kinase and mitogen activated protein kinase was equivalent between CD45- and CD45+ cells
Bode et al., J Hepatol 1998
:
The
mitogen activated protein kinase-kinase inhibitor PD 098059 abolished phosphorylation of the extracellular signal regulated kinases-1 and -2 in response to lipopolysaccharide, irrespective of the medium osmolarity, and
diminished lipopolysaccharide induced
interleukin-6 mRNA expression and interleukin-6 production under normo- and hypoosmotic conditions by about 50 % ; it also resulted under hyperosmotic conditions in an about 80 % inhibition