Gene interactions and pathways from curated databases and text-mining

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IL6 — PTGS1

Text-mined interactions from Literome

Pagel et al., Bone 2009 : Furthermore, in the presence of the selective cyclooxygenase-1 and -2 inhibitors SC-560 and NS-398 thrombin induced interleukin-6 release was prevented
Tai et al., Endocrinology 1997 : In mouse osteoblastic cells, both IL-1alpha and IL-6 with sIL-6R markedly induced messenger RNA expression of COX-2, but not COX-1 , as determined by Northern blot analysis, and luciferase activity in cells stably transfected with a COX-2 promoter-luciferase fusion construct
Williams et al., J Biol Chem 1997 : The experimental findings demonstrate that the effects of Cox-1 and Cox-2 activity on macrophage IL-6 synthesis are segregated
Longo et al., Mediators Inflamm 1998 : The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation