Gene interactions and pathways from curated databases and text-mining

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BCL2 — HMOX1

Text-mined interactions from Literome

Tsui et al., Biochem Biophys Res Commun 2005 : Heme oxygenase-1 could induce the expression of anti-apoptotic protein-Bcl-xL in human hepatocyte
Botros et al., Cell Mol Biol Incl Cyto Enzymol 2007 (Hypertension, Renovascular) : In clipped kidneys from 2K1C rats, inhibition of HO activity by SnMP augmented caspase-3 and caspase-9 activity and decreased expression of the anti-apoptotic Bcl-2 protein, while induction of HO-1 with CoPP strongly inhibited the activity of both caspases and increased the induction of Bcl-2 and Bcl-xl proteins
Asija et al., Antioxid Redox Signal 2007 (Hyperglycemia) : Selective expression of HO-1 prevented TNF- and hyperglycemia mediated superoxide ( O2- ) formation, DNA degeneration, and upregulation of caspase, but increased the expression of pAkt and Bcl-xL , proteins responsible for endothelial dysfunction in diabetes
Sue et al., Nephrol Dial Transplant 2009 (Disease Models, Animal...) : We evaluated the protective effects of HO-1 on several apoptotic parameters induced by gentamicin : cleaved caspases-3 and -9, cycloxygenase-2 (Cox-2) and subcellular localization of nuclear factor kappa B-p65 ( NF-kappaB-p65 ), Bcl-xl and HS-1 associated protein ( Hax-1 ) in NRK-52E cells
Nan et al., Lipids in health and disease 2010 (Fatty Liver) : Induction of HO-1 by hemin or Ad-HO-1 significantly attenuated the severity of liver histology, which was associated with decreased hepatic lipid peroxidation content, reduced number of apoptotic cells by TUNEL staining, down-regulated expression of pro-apoptosis related genes including Fas/FasL, Bax, caspase-3 and caspase-9, reduced expression of cytochrome p4502E1 (CYP2E1), inhibited cytochrome c ( Cyt-c ) release, and up-regulated expression of anti-apoptosis gene Bcl-2
Pourzand et al., Cancer Res 1997 : As a marker of oxidative stress, we monitored the effect of Bcl-2 overexpression on the level of HO-1 mRNA accumulation after UVA irradiation ... The results showed that the overexpression of Bcl-2 in the R6 fibroblasts strongly reduces the level of HO-1 induction from 12.5- to 4.9-fold