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BCL2 — HMOX1
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Tsui et al., Biochem Biophys Res Commun 2005
:
Heme oxygenase-1 could
induce the expression of anti-apoptotic
protein-Bcl-xL in human hepatocyte
Botros et al., Cell Mol Biol Incl Cyto Enzymol 2007
(Hypertension, Renovascular) :
In clipped kidneys from 2K1C rats, inhibition of HO activity by SnMP augmented caspase-3 and caspase-9 activity and decreased expression of the anti-apoptotic Bcl-2 protein, while induction of
HO-1 with CoPP strongly inhibited the activity of both caspases and
increased the induction of Bcl-2 and
Bcl-xl proteins
Asija et al., Antioxid Redox Signal 2007
(Hyperglycemia) :
Selective expression of
HO-1 prevented TNF- and hyperglycemia mediated superoxide ( O2- ) formation, DNA degeneration, and upregulation of caspase, but
increased the expression of pAkt and
Bcl-xL , proteins responsible for endothelial dysfunction in diabetes
Sue et al., Nephrol Dial Transplant 2009
(Disease Models, Animal...) :
We evaluated the protective
effects of
HO-1 on several apoptotic parameters induced by gentamicin : cleaved caspases-3 and -9, cycloxygenase-2 (Cox-2) and subcellular localization of nuclear factor kappa B-p65 ( NF-kappaB-p65 ),
Bcl-xl and HS-1 associated protein ( Hax-1 ) in NRK-52E cells
Nan et al., Lipids in health and disease 2010
(Fatty Liver) :
Induction of
HO-1 by hemin or Ad-HO-1 significantly
attenuated the severity of liver histology, which was associated with decreased hepatic lipid peroxidation content, reduced number of apoptotic cells by TUNEL staining, down-regulated expression of pro-apoptosis related genes including Fas/FasL, Bax, caspase-3 and caspase-9, reduced expression of cytochrome p4502E1 (CYP2E1), inhibited cytochrome c ( Cyt-c ) release, and up-regulated expression of anti-apoptosis gene
Bcl-2
Pourzand et al., Cancer Res 1997
:
As a marker of oxidative stress, we monitored the
effect of
Bcl-2 overexpression on the level of
HO-1 mRNA accumulation after UVA irradiation ... The results showed that the overexpression of
Bcl-2 in the R6 fibroblasts strongly
reduces the level of
HO-1 induction from 12.5- to 4.9-fold