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CDKN1A — TP63
Pathways - manually collected, often from reviews:
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NCI Pathway Database Validated transcriptional targets of TAp63 isoforms:
TAp63a (tetramer) complex (TP63)
→
p21CIP1 (CDKN1A)
(transcription, activates)
Guo et al., Nat Cell Biol 2009*, Deutsch et al., Cell 2011*, Yang et al., Mol Cell 1998*
Evidence: reporter gene, physical interaction
-
NCI Pathway Database Validated transcriptional targets of TAp63 isoforms:
TAp63g (tetramer)/NIR complex (TP63-NOC2L)
→
p21CIP1 (CDKN1A)
(transcription, inhibits)
MacPartlin et al., J Biol Chem 2005, Guo et al., Nat Cell Biol 2009*, Heyne et al., Nucleic Acids Res 2010*, Deutsch et al., Cell 2011*
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated transcriptional targets of TAp63 isoforms:
TAp63g (tetramer)/p300 complex (TP63-EP300)
→
p21CIP1 (CDKN1A)
(transcription, activates)
MacPartlin et al., J Biol Chem 2005, Guo et al., Nat Cell Biol 2009*, Heyne et al., Nucleic Acids Res 2010*, Deutsch et al., Cell 2011*
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated transcriptional targets of TAp63 isoforms:
TAp63g (tetramer)/p300 complex (TP63-EP300)
→
p21CIP1 (CDKN1A)
(transcription, activates)
MacPartlin et al., J Biol Chem 2005, Kommagani et al., Oncogene 2006*, Guo et al., Nat Cell Biol 2009*, Deutsch et al., Cell 2011*
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated transcriptional targets of TAp63 isoforms:
TAp63g (tetramer)/p14ARF complex (TP63-CDKN2A)
→
p21CIP1 (CDKN1A)
(transcription, inhibits)
MacPartlin et al., J Biol Chem 2005, Kommagani et al., Oncogene 2006*, Guo et al., Nat Cell Biol 2009*, Deutsch et al., Cell 2011*
Evidence: mutant phenotype, reporter gene, physical interaction
Text-mined interactions from Literome
Ishida et al., Jpn J Cancer Res 2000
(Neoplasms) :
Ad-p73beta and
Ad-p51A induced endogenous
p21 gene expression more effectively than Ad-p73alpha and Ad-p51B, respectively
Okada et al., Exp Cell Res 2002
(Cell Transformation, Neoplastic) :
Unlike p53 and p51A ( TAp63gamma ), however,
p51B ( TAp63alpha ) did not
activate p21 ( waf1 ) gene expression, nor did it induce apoptosis or hemoglobin production