◀ Back to IRF6
IRF6 — SOD1
Text-mined interactions from Literome
Yu et al., Neurosci Lett 1999
(Glioma) :
The mRNA level of
magnesium-SOD ( Mn-SOD ) was
increased by
LPS in both cells while the expression of constituted SOD ( Cu, Zn-SOD ) was not stimulated by LPS
Brandes et al., Hypertension 1999
(Endotoxemia...) :
LPS also
induced expression of the oxidative stress-sensitive protein manganese
superoxide dismutase
Maehara et al., J Cell Biochem 2000
:
Expression of the manganese
superoxide dismutase ( Mn-SOD ) is
induced by tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), and
lipopolysaccharide (LPS)
Barreca et al., Growth Horm IGF Res 1998
(Sepsis) :
To investigate the potential
regulation of
ALS by
LPS , we measured serum ALS by immunoblot, 5 and 10 h after IP injection of LPS ( 250 or 750 microg/100 g BW vs saline ), in 4-week-old female Wistar rats ( four per group ) ... The decrease in
ALS levels in
response to
LPS was not prevented by exogenous GH
White et al., J Endotoxin Res 2000
:
Whether it also inhibits
LPS induction of manganese
superoxide dismutase ( MnSOD ) is not clear
Ogawa et al., J Immunol 2003
(Inflammation...) :
Manganese
superoxide dismutase expression
increased with repeated
LPS stimulation, with a reduction in intracellular superoxide
Klebanov et al., Biofizika 2003
:
The
effect of
lipopolysaccharides (LPS) and low-power laser radiation on nitric oxide ( NO ) production and the activity of
superoxide dismutase ( SOD ) in rat peritoneal exudate macrophages was investigated ... It was found that
LPS increased NO production and
SOD activity in macrophages in a concentration dependent manner ... This implies that the
LPS induced increase in
SOD activity and NO production were determined by the activation of de novo protein synthesis ( SOD and inducible NO synthase )
Sanchez-Campillo et al., Microbes Infect 2004
:
Expression of hepatocyte
Mn-SOD is also
induced by stimulation with CpG-oligodeoxynucleotides,
LPS , and the mix of IFNgamma, IL-1beta and LPS
Wehrwein et al., Cardiovascular diabetology 2006
(Diabetes Mellitus, Type 1) :
Monocytes were isolated from controls and T1D patients and the
LPS stimulated increase of IL-6, CXCL8, monocyte chemotactic protein 1 ( CCL2, MCP-1 ) and
superoxide dismutase ( SOD 2 ), as well as the LPS mediated decrease of apolipoprotein E (Apo E) in primary human monocytes from controls and T1D patients was determined
Nagasaka et al., Biochem Biophys Res Commun 2007
:
Cycloartenyl ferulate ( CAF ), one of phytosteryl ferulates, significantly reduced
lipopolysaccharide (LPS) induced NO production and mRNA expression of inducible NO synthase and cyclooxygenese-2 but upregulated
SOD activity
Xie et al., Int Immunopharmacol 2009
(Acute Disease...) :
Consistent with its effects on neutrophil infiltration, LF treatment significantly increased
LPS induced BALF
superoxide dismutase activity, and significantly decreased lung myeloperoxidase activity as well
Chen et al., Inflammation 2010
(Acute Lung Injury...) :
Furthermore, valnemulin significantly increases
LPS induced
SOD activity in BALF and decreases lung MPO activity as well
Stefanova et al., Z Naturforsch C 2010
(Arthritis, Experimental...) :
Yeast
SOD treatment effectively suppressed the spontaneous and recombinant mouse IFN-gamma +
LPS induced release of NO as well
Laskin et al., J Leukoc Biol 2010
(Acute Disease...) :
LPS induced up-regulation of
SOD was also reduced in STK-/- mice in liver macrophages and endothelial cells
Visner et al., Am J Physiol 1991
:
The
induction of Mn
SOD by
LPS was blocked by both a RNA synthesis inhibitor, actinomycin D, and a protein synthesis inhibitor, cycloheximide
Kaneko et al., Clin Exp Pharmacol Physiol 2012
(Neurodegenerative Diseases) :
LPS did not
affect the expression of Cu/Zn- and
Mn-SOD proteins, nor did it extend the life span of microglia that had mutated Toll-like receptor (TLR) 4
Mokuno et al., J Neurochem 1994
:
To determine whether cytokines or
lipopolysaccharide (LPS) are
involved in the induction of
superoxide dismutase ( SOD ) in the nervous system, we examined the effects of these substances on the levels of SOD in cultured mouse astrocytes ... The results indicate that the selective
induction of Mn
SOD by cytokines and
LPS , which has been observed in nonnervous tissues, may also occur in nervous tissues
Liu et al., J Formos Med Assoc 1996
(Gingival Hyperplasia) :
To determine whether
lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF-alpha) are
involved in the induction of
superoxide dismutase ( SOD ) in gingival tissue, we examined their effect on induction of SOD isozymes in cultured normal ( NGF ) and phenytoin induced hyperplastic ( PHF ) gingival fibroblasts
De Leo et al., FEBS Lett 1997
(Liver Neoplasms, Experimental) :
Iron modulation of
LPS induced manganese
superoxide dismutase gene expression in rat tissues
Dobashi et al., J Neurochem 1997
:
In spite of the stimulation of mRNA level,
LPS and IFN-gamma significantly
inhibited the activity of
Mn-SOD within the first 24 h of incubation ; however, Mn-SOD activity gradually increased with the increase in time of incubation
Sugino et al., Biol Reprod 1998
:
LPS caused an increase in
Mn-SOD mRNA levels in the corpus luteum and a decrease in serum progesterone levels, but neither in levels of Cu, Zn-SOD mRNA